Rabbit Polyclonal IMP4 Antibody

IMP4 (IGF2 mRNA-binding protein 4) is a conserved RNA-binding protein belonging to the IMP/Emerin family, which plays critical roles in RNA metabolism, ribosome biogenesis, and cellular proliferation. It contains characteristic KH and K-homology domains that mediate interactions with RNA molecules, particularly during rRNA processing and 40S ribosomal subunit assembly in the nucleolus. IMP4 is essential for embryonic development and cell cycle progression, particularly in G1/S phase transition. Dysregulation of IMP4 has been linked to various diseases. Overexpression is observed in multiple cancers (e.g., hepatocellular carcinoma, breast cancer) and correlates with poor prognosis, likely due to its role in promoting cell proliferation and genomic instability. Conversely, reduced IMP4 activity is associated with developmental disorders like X-linked intellectual disability. IMP4 antibodies are widely used as research tools to investigate its localization (nucleolar/cytoplasmic distribution), expression patterns, and molecular interactions. They enable techniques such as Western blotting, immunofluorescence, and co-immunoprecipitation, aiding studies on ribosomopathies, oncogenesis, and neurodevelopmental defects. Recent studies also explore IMP4's potential as a therapeutic target or biomarker in precision oncology.