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Rabbit Polyclonal IMP4 Antibody

  • 中文名： IMP4抗体
  • 别    名： U3 small nucleolar ribonucleoprotein protein IMP4, U3 snoRNP protein IMP4, Brix domain-containing protein 4, IMP4, BXDC4
货号: IPDX34216
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/10-1/50 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesU3 small nucleolar ribonucleoprotein protein IMP4, U3 snoRNP protein IMP4, Brix domain-containing protein 4, IMP4, BXDC4
Entrez GeneID92856
WB Predicted band size33.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis IMP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-243 amino acids from the C-terminal region of human IMP4.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于IMP4抗体的3篇参考文献示例(注：以下内容为示例性模拟，实际文献请通过学术数据库验证)：

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1. **标题**: *IMP4 Drives Hepatocellular Carcinoma Progression via Cell Cycle Dysregulation*

**作者**: Li, X. et al. (2020)

**摘要**: 该研究通过Western blot和免疫组化(使用IMP4特异性抗体)分析肝癌组织中IMP4的表达，发现其高表达与患者预后不良相关。机制研究表明，IMP4通过调控Cyclin D1/CDK4通路促进细胞周期进展并抑制凋亡。

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2. **标题**: *IMP4 as a Diagnostic Biomarker in Gastric Cancer: A Tissue Microarray Study*

**作者**: Wang, Y. et al. (2021)

**摘要**: 研究利用组织微阵列技术结合IMP4抗体进行免疫组化分析，发现IMP4在胃癌组织中显著过表达，且与肿瘤分化程度和淋巴结转移相关，提示其作为潜在诊断标志物的价值。

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3. **标题**: *IMP4-LIN28A Interaction Modulates let-7 MicroRNA Biogenesis in Breast Cancer*

**作者**: Chen, L. et al. (2018)

**摘要**: 该研究通过免疫共沉淀(IMP4抗体)和蛋白质印迹证实IMP4与LIN28A的相互作用，揭示其共同调控let-7 microRNA加工，进而影响乳腺癌细胞的干性和化疗耐药性。

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如需获取真实文献，建议在PubMed或Google Scholar中以关键词“IMP4 antibody”、“IMP4 cancer”或“IMP4 biomarker”检索，并筛选涉及IMP4蛋白表达检测或功能研究的文章。

背景信息

IMP4 (IGF2 mRNA-binding protein 4) is a conserved RNA-binding protein belonging to the IMP/Emerin family, which plays critical roles in RNA metabolism, ribosome biogenesis, and cellular proliferation. It contains characteristic KH and K-homology domains that mediate interactions with RNA molecules, particularly during rRNA processing and 40S ribosomal subunit assembly in the nucleolus. IMP4 is essential for embryonic development and cell cycle progression, particularly in G1/S phase transition. Dysregulation of IMP4 has been linked to various diseases. Overexpression is observed in multiple cancers (e.g., hepatocellular carcinoma, breast cancer) and correlates with poor prognosis, likely due to its role in promoting cell proliferation and genomic instability. Conversely, reduced IMP4 activity is associated with developmental disorders like X-linked intellectual disability. IMP4 antibodies are widely used as research tools to investigate its localization (nucleolar/cytoplasmic distribution), expression patterns, and molecular interactions. They enable techniques such as Western blotting, immunofluorescence, and co-immunoprecipitation, aiding studies on ribosomopathies, oncogenesis, and neurodevelopmental defects. Recent studies also explore IMP4's potential as a therapeutic target or biomarker in precision oncology.

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