| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Thrombospondin-type laminin G domain and EAR repeat-containing protein, TSP-EAR, TSPEAR, C21orf29 |
| Entrez GeneID | 54084 |
| WB Predicted band size | 74.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This C21orf29 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-320 amino acids from the Central region of human C21orf29. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是关于C21orf29抗体的示例参考文献(注：以下内容为模拟示例，实际文献需通过学术数据库验证)：
---
1. **文献名称**: *Characterization of a novel polyclonal antibody against human C21orf29 protein*
**作者**: Smith A, et al.
**摘要**: 该研究开发并验证了一种兔源多克隆抗体，通过重组C21orf29蛋白免疫制备。抗体在Western blot和免疫组化中显示高特异性，成功用于检测多种癌细胞系中C21orf29的差异表达，提示其与肿瘤进展相关。
2. **文献名称**: *C21orf29 localizes to mitochondria and regulates oxidative phosphorylation*
**作者**: Johnson R, et al.
**摘要**: 利用小鼠单克隆抗体进行免疫荧光和亚细胞分馏实验，发现C21orf29定位于线粒体，并参与调控氧化磷酸化过程。研究为理解其代谢功能提供了实验工具。
3. **文献名称**: *C21orf29 expression is altered in Alzheimer's disease models*
**作者**: Lee S, et al.
**摘要**: 研究通过商业化C21orf29抗体(货号AB123. XYZ公司)分析阿尔茨海默病模型小鼠脑组织，发现蛋白表达水平显著下降，提示其可能与神经退行性病变相关。
4. **文献名称**: *Development of a peptide-based antibody for C21orf29 detection in clinical samples*
**作者**: Chen L, et al.
**摘要**: 报道了一种基于C21orf29特异性肽段的多克隆抗体的开发，验证其在福尔马林固定石蜡包埋组织中的适用性，并用于结直肠癌患者的预后分析。
---
**建议**：实际研究中，请通过PubMed、Google Scholar等平台以关键词“C21orf29 antibody”检索最新文献，或查阅抗体供应商(如Abcam、Sigma-Aldrich)提供的引用文献列表。
The C21orf29 antibody is a research tool targeting the protein encoded by the C21orf29 gene (Chromosome 21 Open Reading Frame 29), also known as CXorf29 or C21CR2. This gene, located on human chromosome 21q22.11. encodes a conserved but poorly characterized protein with a predicted molecular weight of ~25 kDa. While its precise biological function remains unclear, C21orf29 is hypothesized to play roles in cellular processes such as DNA repair, mitochondrial function, or RNA metabolism based on sequence homology and limited interactome studies.
Antibodies against C21orf29 have been developed primarily for basic research applications, including Western blotting, immunohistochemistry, and immunofluorescence, to investigate its expression patterns, subcellular localization, and potential interactions. Commercial antibodies are available from multiple suppliers, often validated using overexpression systems or CRISPR/Cas9 knockout controls. Emerging studies suggest associations between C21orf29 and diseases linked to chromosome 21 anomalies, such as Down syndrome, though direct evidence remains sparse. Recent proteomic studies also imply possible involvement in cancer progression and neurological disorders, driving increased interest in this protein.
However, research using C21orf29 antibodies faces challenges due to limited functional data, variable antibody specificity across experimental models, and unresolved discrepancies in reported protein isoforms. Ongoing efforts aim to clarify its molecular mechanisms and validate its potential as a biomarker or therapeutic target.
×
