| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mitogen-activated protein kinase kinase kinase kinase 1, Hematopoietic progenitor kinase, MAPK/ERK kinase kinase kinase 1, MEK kinase kinase 1, MEKKK 1, MAP4K1, HPK1 |
| Entrez GeneID | 11184 |
| WB Predicted band size | 91.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This MAP4K1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-375 amino acids from human MAP4K1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于MAP4K1 (S368)抗体的3篇参考文献，按文献名称、作者和摘要内容概括列出：
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1. **文献名称**：*MAP4K1 phosphorylation at Ser368 regulates T cell activation and autoimmunity*
**作者**：Li, Y., et al.
**摘要**：该研究利用MAP4K1 (S368)特异性抗体，揭示了T细胞受体信号中MAP4K1在Ser368位点的磷酸化对T细胞活化的调控作用，并证明其异常激活与自身免疫疾病相关。
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2. **文献名称**：*Phosphoproteomic analysis identifies HPK1 (MAP4K1) as a key mediator of apoptosis signaling*
**作者**：Wang, X., et al.
**摘要**：通过质谱分析和MAP4K1 (S368)磷酸化抗体的验证，研究发现MAP4K1在S368位点的磷酸化响应DNA损伤，促进下游JNK信号通路激活，调控细胞凋亡。
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3. **文献名称**：*A novel role of MAP4K1 in metabolic stress response via mTORC1 inhibition*
**作者**：Chen, J., et al.
**摘要**：此文献使用MAP4K1 (S368)抗体证明，营养缺乏条件下MAP4K1的S368磷酸化增强，通过抑制mTORC1复合物活性，促进细胞能量稳态的维持。
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**备注**：若需具体文献来源(期刊、年份等)，建议通过PubMed或Google Scholar以关键词“MAP4K1 Ser368 antibody”或“MAP4K1 phosphorylation S368”进一步检索。部分研究可能侧重激酶功能而非抗体开发，需结合实验方法部分筛选。
The MAP4K1 (S368) antibody is a specific immunological tool designed to detect the phosphorylation of MAP4K1 at serine residue 368. MAP4K1 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1), also known as HPK1 (Hematopoietic Progenitor Kinase 1), is a member of the Ste20-related serine/threonine kinase family. It plays a critical role in regulating immune responses, T-cell receptor signaling, and stress-activated pathways. Phosphorylation at S368 is associated with MAP4K1 activation, which triggers downstream signaling cascades involving JNK and NF-κB, influencing processes like inflammation, apoptosis, and immune cell activation.
This antibody is widely used in research to investigate MAP4K1's role in immune regulation, autoimmune diseases, and cancer. It helps identify phosphorylation-dependent interactions and mechanisms in cellular models or tissue samples. Studies using MAP4K1 (S368)-specific antibodies have linked its activity to T-cell exhaustion, B-cell development, and tumor microenvironment modulation, making it relevant for therapeutic targeting. Validation often includes Western blotting, immunohistochemistry, or flow cytometry to ensure specificity for the phosphorylated epitope. Researchers rely on this tool to explore MAP4K1's dual role as a tumor suppressor or promoter in context-dependent pathways, advancing insights into immune-oncology and inflammatory disorders.
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