Rabbit Polyclonal LUC7L Antibody

The LUC7L antibody is a tool used to study the LUC7-like protein 1 (LUC7L), a component of the human spliceosome complex involved in pre-mRNA processing. LUC7L, encoded by the *LUC7L* gene on chromosome 16p13.3. is part of the conserved LUC7 protein family and plays a role in RNA splicing by interacting with U1 small nuclear ribonucleoproteins (snRNPs). It contributes to the recognition of 5' splice sites during early spliceosome assembly. Research links LUC7L to cellular stress responses, DNA repair, and transcriptional regulation, with dysregulation implicated in diseases such as myelodysplastic syndromes (MDS) and certain cancers. For example, reduced LUC7L expression has been associated with poor prognosis in leukemia and colorectal cancer. LUC7L antibodies are typically developed in rabbits or mice using immunogenic peptide sequences or recombinant protein fragments. These antibodies enable detection of endogenous LUC7L via techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding investigations into its molecular interactions and disease mechanisms. Validation often includes knockout cell lines to confirm specificity. Commercial LUC7L antibodies are widely used in basic research to explore RNA splicing defects, cancer biology, and therapeutic targets. However, variability in antibody performance across experimental conditions requires careful optimization. Ongoing studies continue to uncover LUC7L's role in maintaining genomic stability and its potential as a biomarker or therapeutic target.