| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ferritin heavy chain, Ferritin H subunit, Cell proliferation-inducing gene 15 protein, Ferritin heavy chain, N-terminally processed, FTH1, FTH, FTHL6 |
| Entrez GeneID | 2495 |
| WB Predicted band size | 21.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This FTH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-183 amino acids from the C-terminal region of human FTH1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FTH1抗体的参考文献示例(内容基于典型研究方向，文献名称和作者为虚拟示例)：
1. **文献名称**：*"FTH1-Mediated Ferritinophagy Drives Hepatocellular Carcinoma Progression via Regulation of Cellular Iron Homeostasis"*
**作者**：Zhang L, et al.
**摘要内容**：通过免疫组化和Western blot分析，研究发现FTH1抗体检测到肝癌组织中FTH1表达升高，其通过调控铁自噬(ferritinophagy)促进肿瘤生长和转移。
2. **文献名称**：*"FTH1 Antibody Reveals Synaptic Iron Accumulation in Alzheimer’s Disease Models"*
**作者**：Smith J, et al.
**摘要内容**：利用FTH1抗体对阿尔茨海默病小鼠脑组织进行染色，发现FTH1在神经元突触区域异常聚集，提示铁代谢紊乱可能参与神经退行性病变。
3. **文献名称**：*"Targeting FTH1 Enhances Chemosensitivity in Triple-Negative Breast Cancer through ROS-Mediated Apoptosis"*
**作者**：Wang Y, et al.
**摘要内容**：通过FTH1抗体检测临床样本和细胞系，发现抑制FTH1可增加细胞内活性氧(ROS)水平，从而增强化疗药物对三阴性乳腺癌细胞的杀伤作用。
4. **文献名称**：*"FTH1 Antibody Validation for Flow Cytometry: Implications in Immune Cell Iron Metabolism"*
**作者**：Chen R, et al.
**摘要内容**：研究验证了FTH1抗体在流式细胞术中的特异性，并揭示巨噬细胞中FTH1表达动态变化与炎症状态下铁再分布的关系。
(注：以上为模拟示例，实际文献需通过学术数据库检索确认。)
Ferritin Heavy Chain 1 (FTH1) is a key subunit of the ferritin complex, a major cellular iron storage protein that regulates iron homeostasis by sequestering excess iron in a nontoxic and bioavailable form. FTH1. encoded by the *FTH1* gene, possesses ferroxidase activity critical for converting Fe²⁺ to Fe³⁺, enabling iron incorporation into the ferritin mineral core. This process protects cells from iron-induced oxidative stress and maintains cellular iron balance. Dysregulation of FTH1 is linked to iron metabolism disorders, neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s), and cancers, where altered iron dynamics influence tumor progression and therapeutic resistance.
FTH1 antibodies are essential tools for detecting and quantifying FTH1 expression in research and diagnostics. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study tissue-specific or subcellular FTH1 localization, iron storage capacity, and responses to oxidative stress or iron overload. Commercially available FTH1 antibodies are typically raised against specific epitopes of human or murine FTH1. with validation across species and applications. Recent studies also explore FTH1’s role in ferroptosis, a regulated cell death pathway driven by iron-dependent lipid peroxidation, highlighting its therapeutic relevance. However, antibody specificity remains a consideration, as ferritin complexes share structural homology across subunits. Proper controls are necessary to distinguish FTH1 from its light chain counterpart (FTL) or isoform variants.
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