| WB | 1/1000-1/8000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transgelin, 22 kDa actin-binding protein, Protein WS3-10, Smooth muscle protein 22-alpha, SM22-alpha, TAGLN, SM22, WS3-10 |
| Entrez GeneID | 6876 |
| WB Predicted band size | 22.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This TAGLN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-51 amino acids from the N-terminal region of human TAGLN. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于TAGLN (N-term)抗体的参考文献示例(注：文献信息为模拟概括，实际引用需核实原文准确性)：
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1. **文献名称**: *"Transgelin (TAGLN) promotes tumor progression through actin cytoskeleton remodeling in triple-negative breast cancer"*
**作者**: Smith J, et al. (2019)
**摘要**: 研究利用TAGLN (N-term)抗体进行Western blot和免疫组化分析，发现TAGLN在乳腺癌细胞中通过调控肌动蛋白骨架重组促进侵袭转移，抗体特异性验证显示其N端表位的高效识别能力。
2. **文献名称**: *"Smooth muscle-specific transgelin regulates vascular remodeling in atherosclerosis"*
**作者**: Zhang L, et al. (2017)
**摘要**: 通过TAGLN (N-term)抗体的免疫荧光染色，揭示了TAGLN在动脉粥样硬化模型中平滑肌细胞表型转化的关键作用，证实其N端抗体在组织定位研究中的特异性。
3. **文献名称**: *"Transgelin as a biomarker for early-stage colorectal cancer diagnosis"*
**作者**: Kim H, et al. (2020)
**摘要**: 研究采用TAGLN (N-term)抗体进行ELISA和流式细胞术，发现血清TAGLN水平在结直肠癌早期显著升高，表明其作为非侵入性诊断标志物的潜力，抗体灵敏度经质谱验证。
4. **文献名称**: *"TAGLN-mediated cytoskeletal dynamics in pulmonary fibrosis"*
**作者**: Lee S, et al. (2021)
**摘要**: 利用TAGLN (N-term)抗体进行免疫沉淀和共聚焦显微镜观察，发现TAGLN通过调控成纤维细胞肌动蛋白结构驱动肺纤维化进程，抗体特异性通过siRNA敲除实验进一步确认。
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建议通过PubMed或Google Scholar以关键词“TAGLN N-terminal antibody”或“Transgelin antibody application”检索真实文献，并核对实验方法部分的抗体使用信息。
The TAGLN (N-term) antibody is designed to detect the N-terminal region of Transgelin, a 22-kDa protein also known as SM22α. Belonging to the calponin family, Transgelin is an actin-binding protein implicated in cytoskeletal organization and smooth muscle contraction. It is predominantly expressed in smooth muscle cells, fibroblasts, and certain cancer cells. The protein plays roles in cell migration, proliferation, and differentiation, with dysregulation linked to pathologies such as atherosclerosis, fibrosis, and tumor metastasis.
The TAGLN (N-term) antibody is widely used in research to study Transgelin's expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity for the N-terminal region ensures recognition of full-length Transgelin isoforms, aiding in distinguishing them from potential degradation products or splice variants.
Interest in Transgelin has grown due to its dual role as a tumor suppressor or promoter, depending on cancer type and context. In some cancers, its downregulation correlates with epithelial-mesenchymal transition (EMT) and metastasis, while in others, overexpression associates with poor prognosis. The TAGLN (N-term) antibody thus serves as a critical tool for exploring Transgelin's complex roles in normal physiology and disease, offering insights into its potential as a diagnostic marker or therapeutic target.
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