Rabbit Polyclonal Synphilin-1(SNCAIP) Antibody

Synphilin-1. encoded by the *SNCAIP* gene, is a cytoplasmic protein that interacts with α-synuclein, a key player in Parkinson’s disease (PD) pathogenesis. It was initially identified as an α-synuclein-binding partner involved in forming Lewy bodies—protein aggregates characteristic of PD. Synphilin-1 is thought to modulate α-synuclein toxicity by promoting its sequestration into inclusion bodies, potentially influencing disease progression. Antibodies targeting Synphilin-1 are essential tools for studying its expression, localization, and interaction networks in cellular and animal models. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect Synphilin-1 in brain tissues or cultured cells. Researchers also employ them to investigate post-translational modifications (e.g., phosphorylation or ubiquitination) linked to PD pathology. Commercially available Synphilin-1 antibodies are typically raised against specific epitopes, with validation in knockout models ensuring specificity. Their applications extend to exploring Synphilin-1’s role in autophagy, apoptosis, and proteasomal degradation pathways, which are critical for understanding neurodegenerative mechanisms. By enabling precise detection, these antibodies contribute to elucidating Synphilin-1’s dual roles as a neuroprotective scaffold or a pathogenic cofactor in synucleinopathies, aiding therapeutic target discovery.