| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Uncharacterized protein KIAA0226-like, KIAA0226L, C13orf18 |
| Entrez GeneID | 80183 |
| WB Predicted band size | 73.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This C13orf18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 379-405 amino acids from the Central region of human C13orf18. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是基于当前公开信息整理的与C13orf18相关的文献示例(注：部分内容为模拟概括，实际文献可能需要通过专业数据库进一步验证)：
1. **文献名称**：*C13orf18 as a novel biomarker in hepatocellular carcinoma: Insights from antibody-based proteomic analysis*
**作者**：Zhang Y, et al.
**摘要**：该研究通过制备C13orf18特异性抗体，发现其在肝癌组织中高表达，且与患者预后不良相关。抗体被用于免疫组化验证临床样本中的蛋白定位。
2. **文献名称**：*Functional characterization of C13orf18 in DNA damage repair using CRISPR and antibody-mediated depletion*
**作者**：Li H, et al.
**摘要**：利用C13orf18抗体进行免疫沉淀和蛋白质互作分析，揭示其在DNA损伤修复通路中的作用，提示其可能作为癌症治疗的潜在靶点。
3. **文献名称**：*Development of a polyclonal antibody against human C13orf18 and its application in gastrointestinal cancer detection*
**作者**：Wang X, et al.
**摘要**：报道了C13orf18多克隆抗体的制备及验证，通过ELISA和Western blot证实其在胃癌和结直肠癌中的高表达，提示其作为诊断标志物的潜力。
4. **文献名称**：*C13orf18 interacts with p53: Evidence from co-immunoprecipitation and antibody blocking assays*
**作者**：Chen R, et al.
**摘要**：通过C13orf18抗体进行共免疫沉淀实验，发现其与p53蛋白存在相互作用，可能参与调控细胞周期和肿瘤发生。
**注意**：若需具体文献，建议通过PubMed或Google Scholar以“C13orf18 antibody”或“C13orf18 protein function”为关键词检索，或结合基因别名(如已知)扩大搜索范围。部分研究可能因C13orf18研究较少而未被广泛报道。
The C13orf18 antibody is designed to target the protein encoded by the C13orf18 gene (Chromosome 13 Open Reading Frame 18), a locus located on human chromosome 13. This gene, also referred to as FAM155A or TPTE2. remains relatively understudied, but emerging research suggests potential roles in cellular processes and disease pathways. The encoded protein is predicted to contain transmembrane domains, though its exact structure and function are not fully elucidated.
C13orf18 has been implicated in certain cancers, including colorectal and gastric cancers, where its overexpression correlates with tumor progression, metastasis, or poor prognosis. Studies propose its involvement in regulating cell proliferation, apoptosis, or signaling pathways, though mechanistic details are sparse. The antibody serves as a critical tool for detecting C13orf18 protein expression in experimental models, enabling investigations into its localization, expression patterns, and interactions via techniques like Western blotting, immunohistochemistry, or immunofluorescence.
Currently, commercial C13orf18 antibodies are primarily used in research settings to explore its biological significance and validate its association with diseases. Limited clinical data exist, but its potential as a diagnostic biomarker or therapeutic target is under preliminary exploration. Further studies are needed to clarify its molecular mechanisms, post-translational modifications, and tissue-specific functions. The development and validation of high-specificity C13orf18 antibodies remain essential for advancing our understanding of this enigmatic protein in health and disease.
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