| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | 26S proteasome non-ATPase regulatory subunit 13, 26S proteasome regulatory subunit RPN9, 26S proteasome regulatory subunit S11, 26S proteasome regulatory subunit p405, PSMD13 |
| Entrez GeneID | 5719 |
| WB Predicted band size | 42.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PSMD13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 269-298 amino acids from the C-terminal region of human PSMD13. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PSMD13抗体的参考文献示例(注：以下内容为模拟生成，实际文献可能需要通过学术数据库验证)：
1. **文献名称**: "Characterization of PSMD13 in the 19S Proteasome Regulatory Particle"
**作者**: Tanaka K, et al.
**摘要**: 该研究通过免疫沉淀和Western blot技术，利用PSMD13抗体鉴定了其在19S蛋白酶体调节颗粒中的定位，揭示了其与其他亚基的相互作用，并证明其在蛋白质降解中的关键作用。
2. **文献名称**: "PSMD13 Overexpression in Breast Cancer and Its Clinical Implications"
**作者**: Smith J, et al.
**摘要**: 研究使用PSMD13抗体进行免疫组化分析，发现PSMD13在乳腺癌组织中高表达，且与患者预后不良相关，提示其作为潜在治疗靶点的可能性。
3. **文献名称**: "Role of PSMD13 in Neurodegenerative Protein Aggregation"
**作者**: Chen L, et al.
**摘要**: 通过Western blot和免疫荧光技术，结合PSMD13抗体，研究发现PSMD13在阿尔茨海默病模型中表达下调，可能影响异常蛋白的清除效率。
4. **文献名称**: "Proteasome Assembly and PSMD13 Functional Analysis"
**作者**: Murata S, et al.
**摘要**: 利用PSMD13抗体进行蛋白质复合物分离实验，阐明了PSMD13在蛋白酶体组装过程中的作用及其对细胞周期调控的影响。
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建议通过PubMed或Google Scholar以关键词“PSMD13 antibody”、“proteasome PSMD13”等检索真实文献，并核对具体应用场景。
The PSMD13 antibody is a research tool designed to detect and study the 26S proteasome non-ATPase regulatory subunit 13. a critical component of the 19S regulatory particle within the 26S proteasome complex. The 26S proteasome is central to the ubiquitin-proteasome system (UPS), responsible for targeted protein degradation in eukaryotic cells. PSMD13. also known as RPN9. plays a role in substrate recognition, deubiquitination, and unfolding during proteasomal degradation, ensuring cellular protein homeostasis. Dysregulation of proteasome activity is linked to cancers, neurodegenerative disorders, and autoimmune diseases, making PSMD13 a potential biomarker or therapeutic target.
PSMD13 antibodies are widely used in techniques like Western blotting, immunoprecipitation, and immunohistochemistry to analyze protein expression, localization, and interactions. Researchers employ these antibodies to investigate proteasome assembly, UPS-related pathways, and disease mechanisms. Specificity is validated using knockout/knockdown controls or recombinant proteins. Both monoclonal and polyclonal variants are available, typically raised in hosts like rabbits or mice. Recent studies explore PSMD13's role in drug resistance, particularly in cancers treated with proteasome inhibitors like bortezomib. Its expression patterns in pathological tissues further highlight its relevance in translational research.
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