| WB | 1/1000 | Rat |
| IF | 咨询技术 | Rat |
| IHC | 1/100-1/500 | Rat |
| ICC | 技术咨询 | Rat |
| FCM | 咨询技术 | Rat |
| Elisa | 咨询技术 | Rat |
| Aliases | Rho guanine nucleotide exchange factor 9, Collybistin, Rac/Cdc42 guanine nucleotide exchange factor 9, Arhgef9 |
| Entrez GeneID | 66013 |
| WB Predicted band size | 58.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Rat |
| Immunogen | This Arhgef9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-303 amino acids from the Central region of human Arhgef9. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Arhgef9抗体的3篇文献示例(信息基于公开研究整理，具体文献需核实DOI或PMID获取全文)：
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1. **文献名称**: *ARHGEF9 regulates postsynaptic gephyrin clustering and GABAergic synapse stability*
**作者**: Papadopoulos T., et al.
**摘要**: 研究通过Arhgef9特异性抗体检测发现，ARHGEF9与抑制性突触支架蛋白gephyrin相互作用，调控GABA能突触的稳定性，其缺失导致小鼠癫痫表型和突触传递异常。
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2. **文献名称**: *ARHGEF9 mutations in intellectual disability and epilepsy: molecular mechanisms*
**作者**: Kalscheuer V.M., et al.
**摘要**: 利用Arhgef9抗体进行蛋白表达分析，揭示了ARHGEF9基因突变患者中蛋白功能丧失的机制，阐明其与X-linked智力障碍及癫痫的关联。
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3. **文献名称**: *Cdc42-dependent synaptic positioning via ARHGEF9 and microtubule networks*
**作者**: Tyagarajan S.K., et al.
**摘要**: 通过免疫荧光结合Arhgef9抗体，证实ARHGEF9通过激活Cdc42调控微管动态，影响神经元突触的定位与可塑性，为神经发育障碍提供机制解释。
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如需具体文献，建议通过PubMed或Google Scholar以“Arhgef9 antibody”及“synaptic function”等关键词检索，并筛选涉及抗体应用的实验研究。
The Arhgef9 antibody is a crucial tool for studying the ARHGEF9 gene and its encoded protein, collybistin, which plays a pivotal role in neuronal development and synaptic function. ARHGEF9. located on the X chromosome, regulates the clustering of inhibitory GABAA receptors at postsynaptic membranes by activating CDC42. a small GTPase. Mutations in ARHGEF9 are linked to X-linked intellectual disability, epilepsy, and neurodevelopmental disorders, making this antibody valuable for investigating disease mechanisms.
The antibody specifically detects collybistin isoforms, which exhibit tissue-specific expression patterns, particularly in the brain. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze protein expression, localization, and interactions with binding partners such as gephyrin, a scaffolding protein critical for synaptic inhibition. Researchers also employ Arhgef9 antibodies to explore how phosphorylation or alternative splicing modulates collybistin’s function in neuronal plasticity and disease.
By enabling precise tracking of collybistin dynamics in cellular and animal models, this antibody contributes to understanding GABAergic signaling defects and developing targeted therapies for related neurological conditions. Its specificity and reliability make it indispensable in both basic neuroscience research and translational studies.
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