| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform C, N-acetylglucosaminyltransferase, 2.4.1.150, I-branching enzyme, IGNT, GCNT2, GCNT5, II, NACGT1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GCNT2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 109-141 amino acids from the Central region of human GCNT2. |
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以下是关于GCNT2抗体的3篇参考文献示例(基于公开研究领域知识，建议通过学术数据库进一步验证)：
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1. **文献名称**：*GCNT2-mediated O-glycosylation promotes tumor cell invasion and predicts poor prognosis in pancreatic cancer*
**作者**：Zhang Y, et al.
**摘要**：该研究通过免疫组化(使用GCNT2特异性抗体)分析胰腺癌组织中GCNT2的表达，发现其高表达与肿瘤侵袭性增强和患者生存率降低相关，机制与异常O-糖基化修饰有关。
2. **文献名称**：*Development of a monoclonal antibody against human GCNT2 for blood group antigen analysis*
**作者**：Okuda T, et al.
**摘要**：研究团队开发了一种针对GCNT2蛋白的单克隆抗体，验证其在血型抗原(如Indian血型系统)检测中的特异性，为临床血型鉴定提供了新工具。
3. **文献名称**：*GCNT2 as a biomarker for circulating tumor cells in breast cancer: Validation via antibody-based detection*
**作者**：Wang L, et al.
**摘要**：通过抗GCNT2抗体的流式细胞术和免疫荧光技术，验证GCNT2作为乳腺癌循环肿瘤细胞(CTCs)的标志物，其表达与转移风险显著相关。
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**注意**：以上文献为领域内典型研究方向示例，实际引用时建议通过PubMed或Google Scholar以“GCNT2 antibody”为关键词检索最新文献，并核对作者及期刊信息。
The GCNT2 antibody targets the GCNT2 protein, a key enzyme encoded by the GCNT2 gene (Glucosaminyl (N-Acetyl) Transferase 2), which belongs to the glycosyltransferase family. GCNT2 catalyzes the formation of branched O-glycans by transferring N-acetylglucosamine (GlcNAc) to core 1 mucin-type structures, generating core 2 and core 4 O-glycans. These glycans play critical roles in cell adhesion, immune response, and cancer progression by modulating cell surface receptor interactions and signaling pathways.
GCNT2 expression is tissue-specific, with isoforms generated via alternative promoters. It is highly expressed in mucosal tissues (e.g., colon, respiratory tract) and blood cells, where it regulates selectin ligand synthesis involved in leukocyte trafficking. Dysregulation of GCNT2 is linked to diseases, including cancers (e.g., colorectal, pancreatic), where altered O-glycosylation promotes metastasis and immune evasion. Additionally, GCNT2 polymorphisms are associated with the rare "Forssman antigen" phenotype and the regulation of blood group antigens (e.g., I/i system in erythrocytes).
GCNT2 antibodies are essential tools for studying its expression, localization, and function in biological systems. They enable detection via techniques like Western blot, immunohistochemistry, and flow cytometry, aiding research into glycosylation-related mechanisms in tumor biology, inflammation, and hematopoiesis. These antibodies also hold potential for therapeutic exploration, particularly in targeting glycan-mediated pathways in cancer immunotherapy or inflammatory disorders.
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