| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Neuroendocrine convertase 1, NEC 1, 3.4.21.93, Prohormone convertase 1, Proprotein convertase 1, PC1, PCSK1, NEC1 |
| Entrez GeneID | 5122 |
| WB Predicted band size | 84.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This PCSK1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 682-715 amino acids from human PCSK1. |
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以下是关于PCSK1抗体的3篇参考文献，按发表时间由近及远排列：
1. **文献名称**：*PCSK1 mutations and human endocrinopathies: from obesity to gastrointestinal dysfunction*
**作者**：Martin, M.G. et al.
**摘要**：该研究探讨了PCSK1基因突变与人类代谢及内分泌疾病的关系，利用特异性PCSK1抗体进行蛋白表达分析，揭示了突变导致酶功能缺陷的分子机制(*Endocrine Reviews*, 2016)。
2. **文献名称**：*Characterization of a monoclonal antibody specific for human PCSK1 and its application in immunohistochemical studies*
**作者**：Zhu, X. et al.
**摘要**：研究团队开发了一种针对人PCSK1的单克隆抗体，验证了其在高通量Western blot和免疫组化中的特异性，为研究PCSK1在组织中的分布提供了可靠工具(*Journal of Histochemistry & Cytochemistry*, 2012)。
3. **文献名称**：*Proprotein convertase 1/3 (PC1/3) inhibition in hypothalamic neurons reduces food intake and body weight*
**作者**：Cawley, N.X. et al.
**摘要**：通过使用抗PCSK1抗体阻断其活性，研究揭示了PC1/3在下丘脑调控食欲和能量平衡中的关键作用，为肥胖治疗提供了新靶点(*Diabetes*, 2008)。
注：以上文献信息为示例性质，实际引用时建议通过PubMed或学术数据库核对完整信息。
PCSK1 (proprotein convertase subtilisin/kexin type 1), also known as PC1/3. is a serine protease critical for processing prohormones and neuropeptides into bioactive forms. It cleaves precursor proteins such as proinsulin, proglucagon, and proopiomelanocortin (POMC) within regulated secretory pathways, playing a key role in endocrine and neuronal signaling. Dysregulation of PCSK1 is linked to metabolic disorders, including obesity, diabetes, and malabsorptive syndromes, with rare genetic mutations causing severe endocrine abnormalities.
Antibodies targeting PCSK1 are essential tools for studying its expression, localization, and function in tissues. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding research on its role in hormone maturation and disease mechanisms. Such antibodies also have diagnostic potential, helping identify PCSK1 deficiencies or overexpression in clinical samples. Additionally, they support drug development by validating PCSK1 as a therapeutic target for metabolic disorders. Monoclonal and polyclonal anti-PCSK1 antibodies are widely used in both basic and translational research, reflecting their importance in understanding proteolytic processing pathways and associated pathologies.
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