Rabbit Polyclonal COXIVIsoform2 Antibody

The COXIV (Cytochrome c Oxidase Subunit 4) Isoform 2 antibody specifically detects the COX4I2 protein, a regulatory subunit of mitochondrial Complex IV (cytochrome c oxidase) in the electron transport chain. COX4I2 is one of two isoforms (COX4I1 and COX4I2) encoded by distinct genes, with COX4I2 exhibiting tissue-specific expression, particularly in lung, brown adipose tissue, and certain endocrine cells. Unlike the ubiquitously expressed COX4I1. COX4I2 is associated with adaptive responses to hypoxia, playing a role in oxygen sensing and metabolic regulation. Studies suggest COX4I2 enhances Complex IV stability under low oxygen and may modulate cellular respiration efficiency. The antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate COX4I2 expression patterns in physiological and pathological contexts, such as hypoxia-related diseases, cancer metabolism, or mitochondrial disorders. Its specificity is critical due to high sequence homology between isoforms, requiring validation via knockout controls. Research on COX4I2 has expanded insights into tissue-specific mitochondrial adaptations, offering potential therapeutic targets for conditions involving oxidative stress or energy dysregulation.