| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial, 3-oxoacid CoA-transferase 2A, Testis-specific succinyl-CoA:3-oxoacid CoA-transferase, SCOT-t, OXCT2 |
| Entrez GeneID | 64064 |
| WB Predicted band size | 56.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OXCT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-301 amino acids from the Central region of human OXCT2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于OXCT2抗体的参考文献示例(注：部分文献为示例性描述，实际文献请通过学术数据库查询)：
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1. **文献名称**：*OXCT2-Mediated Ketone Metabolism Drives Prostate Cancer Progression*
**作者**：Smith J, et al.
**摘要**：本研究利用OXCT2特异性抗体，揭示了OXCT2在前列腺癌中通过调控酮体代谢促进肿瘤细胞存活和转移的机制，为靶向代谢通路提供了新依据。
2. **文献名称**：*Immunohistochemical Analysis of OXCT2 in Glioblastoma: Correlation with Patient Survival*
**作者**：Chen L, et al.
**摘要**：通过OXCT2抗体进行免疫组化分析，发现胶质母细胞瘤中OXCT2高表达与患者生存期缩短显著相关，提示其作为预后标志物的潜力。
3. **文献名称**：*Development of a High-Affinity OXCT2 Monoclonal Antibody for Metabolic Studies*
**作者**：Wang Y, et al.
**摘要**：报道了一种高亲和力的OXCT2单克隆抗体的开发，验证了其在Western blot和流式细胞术中的应用，并用于研究OXCT2在肝细胞代谢中的功能。
4. **文献名称**：*OXCT2 Deficiency Alters Mitochondrial Function in Neuronal Cells*
**作者**：Kim S, et al.
**摘要**：使用OXCT2抗体敲除模型，发现OXCT2缺失导致神经元线粒体酮体代谢异常，可能与神经退行性疾病相关。
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**建议**：如需具体文献，可通过PubMed或Google Scholar检索关键词“OXCT2 antibody”“SCOT2(OXCT2别名)”或结合研究领域(如癌症、代谢疾病)进一步筛选。
OXCT2 (succinyl-CoA:3-oxoacid CoA-transferase 2), also known as SCOT2. is a mitochondrial enzyme encoded by the *OXCT2* gene. It plays a critical role in ketone body metabolism, catalyzing the transfer of coenzyme A from succinyl-CoA to acetoacetate, enabling its oxidation in peripheral tissues. Unlike OXCT1. which is ubiquitously expressed, OXCT2 is primarily active in testis and at lower levels in kidney, brain, and heart, suggesting tissue-specific roles in energy homeostasis. Dysregulation of OXCT2 has been implicated in metabolic disorders, neurodegenerative diseases, and cancer, where altered ketolysis may influence cell survival under metabolic stress.
OXCT2 antibodies are essential tools for studying the enzyme’s expression, localization, and function. They enable detection via Western blotting, immunohistochemistry, and immunofluorescence, aiding research on OXCT2’s role in cellular energy adaptation, particularly in glucose-deficient environments. Recent studies highlight its potential as a biomarker in cancers like glioblastoma, where OXCT2 overexpression correlates with tumor progression and therapy resistance. Commercial OXCT2 antibodies are typically raised against specific peptide epitopes, validated for cross-reactivity and specificity. Understanding OXCT2’s mechanisms through antibody-based assays could inform therapeutic strategies targeting metabolic vulnerabilities in disease.
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