| WB | 1/500 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Zinc finger protein 502, ZNF502 |
| Entrez GeneID | 91392 |
| WB Predicted band size | 62.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ZNF502 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-101 amino acids from the N-terminal region of human ZNF502. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ZNF502(N-term)抗体的3篇参考文献的简要总结(基于模拟数据，实际文献需进一步验证)：
1. **文献名称**：*Development of a Polyclonal Antibody Targeting the N-Terminal Domain of ZNF502 for Functional Studies*
**作者**：Zhang Y, et al.
**摘要**：研究报道了一种针对ZNF502蛋白N端结构域的多克隆抗体的开发，通过免疫印迹和免疫荧光验证其特异性，并用于检测ZNF502在多种癌细胞系中的亚细胞定位。
2. **文献名称**：*ZNF502 Modulates DNA Damage Response via Interaction with PARP1: Evidence from Antibody-Based Assays*
**作者**：Wang L, et al.
**摘要**：利用ZNF502(N-term)抗体进行免疫共沉淀实验，揭示ZNF502通过N端结构域与PARP1结合，参与调控DNA损伤修复通路，提示其在基因组稳定性中的作用。
3. **文献名称**：*Expression Profiling of Zinc Finger Proteins in Neurodegenerative Disorders Using Domain-Specific Antibodies*
**作者**：Gupta S, et al.
**摘要**：研究使用ZNF502(N-term)抗体分析阿尔茨海默病患者脑组织样本，发现ZNF502在神经炎症相关区域的表达显著上调，提示其可能参与神经退行性病变的调控。
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**注**：以上为模拟生成的参考文献，实际文献需通过PubMed、Google Scholar等平台检索关键词(如“ZNF502 antibody N-terminal”、“ZNF502 N-term function”)获取。若研究较为冷门，建议查阅抗体供应商(如Abcam、Santa Cruz)的产品说明书引用的文献。
The ZNF502 (N-term) antibody is designed to target the N-terminal region of zinc finger protein 502 (ZNF502), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein (ZNF) family. These proteins are characterized by tandem C2H2-type zinc finger motifs involved in DNA binding and a KRAB domain at the N-terminus, which typically mediates transcriptional repression by recruiting chromatin-modifying complexes. ZNF502 is thought to play roles in gene regulation, cellular differentiation, and development, though its specific biological functions remain less characterized compared to other ZNF proteins.
The antibody is commonly used in research applications such as Western blotting, immunohistochemistry, or immunofluorescence to study ZNF502 expression, localization, and interaction partners. It is often raised in rabbits or mice using synthetic peptides or recombinant protein fragments corresponding to the N-terminal region, ensuring specificity for ZNF502 over homologous proteins. Validation may include knockout cell lines or tissues to confirm absence of signal.
Studies employing this antibody may explore ZNF502's potential involvement in developmental processes, cancer (e.g., as a tumor suppressor or oncogene), or neurological disorders, given the KRAB-ZNF family's links to these pathways. Researchers also use it to investigate post-translational modifications or tissue-specific expression patterns, contributing to broader understanding of KRAB-ZNF protein networks in epigenetic regulation.
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