| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Glycosyltransferase-like domain-containing protein 1, Mat-Xa, GTDC1 |
| Entrez GeneID | 79712 |
| WB Predicted band size | 52.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This GTDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 278-304 amino acids from the Central region of human GTDC1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于GTDC1抗体的示例参考文献(注：以下内容为虚构示例，仅供参考格式)：
1. **文献名称**: "Development of a Monoclonal Antibody Against GTDC1 for Detection of Ovarian Cancer Biomarkers"
**作者**: Zhang Y, Liu R, Wang H.
**摘要**: 本研究报道了一种新型抗GTDC1单克隆抗体的开发，并验证了其在卵巢癌组织中的特异性结合能力。通过免疫组化分析，发现GTDC1在卵巢癌中的高表达与患者化疗耐药性显著相关，提示其作为预后标志物的潜力。
2. **文献名称**: "GTDC1 Antibody-Based Functional Study Reveals Its Role in Breast Cancer Cell Invasion"
**作者**: Smith JA, Patel K, Lee C.
**摘要**: 利用抗GTDC1抗体进行的体外功能实验表明，抑制GTDC1可降低乳腺癌细胞的迁移和侵袭能力。研究进一步通过RNA干扰和抗体阻断实验证实，GTDC1通过调控Wnt/β-catenin信号通路促进肿瘤进展。
3. **文献名称**: "Epitope Mapping of GTDC1 Using Polyclonal Antibodies for Structural Analysis"
**作者**: Brown T, Müller S, García-Sánchez A.
**摘要**: 本研究通过多克隆抗体对GTDC1蛋白的表位进行定位，结合X射线晶体学解析了其关键功能结构域。该抗体为后续研究GTDC1在糖基化修饰中的作用提供了工具。
4. **文献名称**: "A Novel GTDC1 Antibody-Based ELISA for Early Diagnosis of Hepatocellular Carcinoma"
**作者**: Chen L, Kim D, Tanaka M.
**摘要**: 研究团队建立了一种基于抗GTDC1抗体的ELISA检测方法，用于肝癌患者血清中GTDC1水平的定量分析。临床数据显示，GTDC1在早期肝癌患者中显著升高，具有高敏感性和特异性。
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**提示**：若需真实文献，建议在PubMed或Web of Science中检索“GTDC1 antibody”及相关关键词，筛选近年研究。部分真实研究可能涉及GTDC1在肿瘤或神经系统疾病中的功能。
The GTDC1 (Glycoprotein Transmembrane Domain Containing 1) antibody is a tool used to study the function and expression of the GTDC1 protein, a poorly characterized transmembrane glycoprotein. GTDC1 is encoded by the *GTDC1* gene, located on human chromosome 2. and is predicted to contain a single-pass transmembrane domain, suggesting involvement in cell membrane-related processes. Though its precise biological role remains unclear, GTDC1 is hypothesized to participate in cell adhesion, signaling, or protein-protein interactions due to structural features shared with other glycoproteins.
Research using GTDC1 antibodies has primarily focused on its expression patterns in tissues, with studies indicating elevated levels in the brain, particularly in neurons, implying a potential role in neurological functions or disorders. Additionally, GTDC1 has been investigated in cancer contexts, as aberrant expression has been observed in certain tumors, though findings remain preliminary. The antibody is commonly employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect GTDC1 in cellular or tissue samples.
Despite limited mechanistic insights, GTDC1 antibodies are valuable for exploring its interaction networks and post-translational modifications, such as glycosylation. Challenges include verifying specificity due to the protein’s low abundance and cross-reactivity risks. Ongoing studies aim to clarify GTDC1’s physiological and pathological relevance, particularly in neurodevelopment and oncogenesis.
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