| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Olfactory receptor 4X1, Olfactory receptor OR11-104, OR4X1 |
| Entrez GeneID | 390113 |
| WB Predicted band size | 34.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OR4X1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human OR4X1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于OR4X1 (N-term)抗体的3篇参考文献及其摘要内容的简要概括：
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1. **文献名称**: *"Characterization of olfactory receptor OR4X1 expression in human tissues using a novel N-terminal antibody"*
**作者**: Smith J, et al.
**摘要**: 该研究开发了一种针对OR4X1蛋白N端表位的特异性抗体，并通过免疫组化验证其在嗅觉上皮和睾丸组织中的选择性表达，提示OR4X1可能参与非嗅觉功能。
2. **文献名称**: *"Antibody validation for GPCRs: A case study on olfactory receptor OR4X1"*
**作者**: Lee S, et al.
**摘要**: 文章系统验证了OR4X1抗体的特异性，包括Western blot、免疫荧光和siRNA敲除实验，证实其N-term抗体能特异性识别内源性OR4X1蛋白，为GPCR抗体标准化提供参考。
3. **文献名称**: *"OR4X1 as a potential biomarker in neuroendocrine tumors: Immunohistochemical insights"*
**作者**: García R, et al.
**摘要**: 利用商业化的OR4X1 N-term抗体，研究发现该受体在部分神经内分泌肿瘤中高表达，提示其可能作为诊断标志物或治疗靶点。
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**注**：以上文献为示例，实际文献可能需要通过PubMed或Google Scholar检索关键词(如"OR4X1 antibody"、"OR4X1 N-terminal")获取。如需具体文献链接或补充信息，请进一步说明。
The OR4X1 (N-term) antibody is a specialized tool designed to target the N-terminal region of the Olfactory Receptor Family 4 Subfamily X Member 1 (OR4X1), a protein belonging to the G-protein-coupled receptor (GPCR) superfamily. OR4X1 is part of the olfactory receptor family, which plays a critical role in detecting odorants and mediating signal transduction in sensory neurons. These receptors are characterized by their seven-transmembrane domain structure and involvement in chemosensory pathways. The N-terminal region, located extracellularly, is crucial for ligand binding and receptor activation, making it a focal point for functional studies.
This antibody is typically generated using synthetic peptides corresponding to the N-terminal sequence of OR4X1. often conjugated to immunogenic carriers like KLH to enhance immune response. It is validated for applications such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to study OR4X1 expression patterns, localization, and interactions in biological samples. Researchers employ it to explore OR4X1's role in olfactory signaling, tissue-specific expression, and potential involvement in non-olfactory tissues, which may link to broader physiological or pathological processes, including neurodegenerative diseases or cancer.
Specificity is confirmed through controls like knockout cell lines or blocking peptide assays to ensure minimal cross-reactivity. Its development supports advancing knowledge in neurobiology, sensory perception, and disease mechanisms, offering insights into OR4X1's functional diversity beyond traditional odor detection.
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