| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Host/Isotype | Mouse IgG2a |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Purified recombinant fragment of human GSTT2B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于GSTT2B抗体的假设性参考文献示例(实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*Characterization of GSTT2B-Specific Antibodies for Detecting Human Tissue Expression*
**作者**：Smith A, et al.
**摘要**：本研究开发并验证了一种针对人GSTT2B蛋白的高特异性多克隆抗体。通过免疫印迹和免疫组化实验，证实该抗体可特异性识别GSTT2B，并在肝脏、肾脏组织中检测到其表达，为研究GSTT2B的生物学功能提供工具。
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2. **文献名称**：*Role of GSTT2B in Drug Metabolism: Insights from Antibody-Based Inhibition Studies*
**作者**：Chen L, et al.
**摘要**：利用抗GSTT2B的单克隆抗体，研究团队发现GSTT2B在体外代谢特定化疗药物(如顺铂)中起关键作用。抗体介导的GSTT2B抑制显著降低药物解毒效率，提示其潜在治疗靶点价值。
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3. **文献名称**：*GSTT2B Genetic Variants and Protein Expression in Cancer: An Immunohistochemical Analysis*
**作者**：Wang Y, et al.
**摘要**：通过商业化GSTT2B抗体分析肿瘤组织样本，发现GSTT2B在结直肠癌中表达上调，且与患者生存率负相关。研究支持GSTT2B作为癌症预后标志物的可能性。
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**注意**：以上为基于GST酶相关研究的模拟示例，实际文献需通过PubMed、Web of Science等平台以“GSTT2B antibody”或“GSTT2B function”为关键词检索。
The glutathione S-transferase theta 2B (GSTT2B) antibody is a tool used to detect and study the GSTT2B protein, a member of the glutathione S-transferase (GST) family. GST enzymes, including GSTT2B, play critical roles in cellular detoxification by catalyzing the conjugation of glutathione to xenobiotics, toxins, and oxidative stress byproducts, aiding their elimination. The GSTT2 gene, located on chromosome 22q11.23. encodes two splice variants: GSTT2A and GSTT2B. While GSTT2B shares high sequence homology with GSTT2A, it differs in its C-terminal region and exhibits distinct substrate preferences.
GSTT2B is expressed in various tissues, including the liver, kidney, and gastrointestinal tract, and is implicated in metabolizing environmental carcinogens, drugs, and endogenous compounds. Dysregulation of GSTT2B has been linked to oxidative stress-related pathologies, such as cancer, neurodegenerative disorders, and drug resistance. The GSTT2B antibody is widely used in techniques like Western blotting, immunohistochemistry, and ELISA to analyze protein expression, localization, and function in both normal and diseased states. Researchers utilize this antibody to explore GSTT2B's role in cellular defense mechanisms, its interaction with therapeutic agents, and its potential as a biomarker for disease susceptibility or treatment response. Validation of GSTT2B antibody specificity is crucial, as cross-reactivity with other GST isoforms (e.g., GSTT1 or GSTT2A) may occur due to structural similarities.
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