| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | VARP; PP12899 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ANKRD27 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于VPREB1抗体的3-4篇参考文献示例(部分信息为虚构示例，仅供参考)：
1. **标题**：*"VPREB1 as a critical component of the pre-B cell receptor complex in B cell development"*
**作者**：Kudo A, Melchers F
**摘要**：本研究阐明了VPREB1在早期B细胞发育中的作用，发现其与λ5蛋白共同组成pre-B细胞受体(pre-BCR)，对抗体轻链的重排和B细胞分化至关重要。
2. **标题**：*"Expression of VPREB1 in primary immunodeficiency disorders: a diagnostic biomarker study"*
**作者**：Schatorje EJ, et al.
**摘要**：通过分析VPREB1抗体在患者样本中的表达水平，提出VPREB1可作为原发性免疫缺陷(如X连锁无丙种球蛋白血症)的辅助诊断标志物，尤其在B细胞发育停滞的病例中。
3. **标题**：*"Autoantibodies targeting VPREB1 in autoimmune diseases: insights from multiple sclerosis cohorts"*
**作者**：Tsuchiya H, et al.
**摘要**：探讨了多发性硬化症患者中VPREB1自身抗体的异常表达，提示其可能与B细胞介导的自身免疫反应相关，为疾病机制研究提供新方向。
4. **标题**：*"VPREB1 antibody-based detection of minimal residual disease in B-cell acute lymphoblastic leukemia"*
**作者**：Müller L, et al.
**摘要**：利用VPREB1抗体开发了一种高灵敏度检测方法，用于追踪B细胞急性淋巴细胞白血病(B-ALL)患者的微小残留病灶(MRD)，并验证其预后价值。
(注：以上文献为示例性内容，实际引用时请核实真实文献信息。)
The VPREB1 antibody targets the VPREB1 (V-set pre-B cell surrogate light chain 1) protein, a critical component in early B-cell development. VPREB1. encoded by the VPREB1 gene, is part of the pre-B cell receptor (pre-BCR) complex, where it pairs with the surrogate heavy chain (λ5) to form the surrogate light chain. This complex plays a pivotal role in B-cell maturation by facilitating the selection and expansion of pre-B cells with functional immunoglobulin heavy chains, a key checkpoint in B-cell differentiation.
VPREB1 is predominantly expressed during the pro-B to pre-B cell transition in the bone marrow. Its expression diminishes as B cells mature, making it a marker for early B-cell precursors. Dysregulation of VPREB1 has been implicated in B-cell malignancies, such as acute lymphoblastic leukemia (ALL), where aberrant pre-BCR signaling can drive leukemogenesis.
Antibodies against VPREB1 are widely used in research to study B-cell development, immune disorders, and hematologic cancers. They enable detection of VPREB1 in techniques like flow cytometry, immunohistochemistry, and Western blotting, aiding in the characterization of B-cell lineage commitment and malignant transformation. Commercial VPREB1 antibodies are typically raised in rabbits or mice, validated for specificity and sensitivity across experimental models. Their application extends to diagnostic contexts, helping identify pre-B cell-derived leukemias and monitor minimal residual disease. Understanding VPREB1's role through these antibodies continues to inform therapeutic strategies targeting B-cell malignancies and immune deficiencies.
×
