Rabbit Polyclonal NSD2 Antibody

The NSD2 antibody is a crucial tool for studying the nuclear receptor-binding SET domain-containing protein 2 (NSD2), also known as WHSC1 or MMSET. NSD2 is a histone methyltransferase that catalyzes dimethylation of histone H3 at lysine 36 (H3K36me2), playing a pivotal role in epigenetic regulation, chromatin remodeling, and gene expression. It gained prominence due to its association with Wolf-Hirschhorn syndrome (a developmental disorder linked to NSD2 haploinsufficiency) and oncogenic roles in cancers, particularly multiple myeloma, where t(4;14) chromosomal translocation leads to NSD2 overexpression. NSD2 antibodies are widely used in research to investigate its expression patterns, subcellular localization, and interactions with chromatin or other proteins. These antibodies enable techniques like Western blotting, immunofluorescence, ChIP-seq, and immunohistochemistry, aiding in the exploration of NSD2's dual role in development and disease. Commercially available NSD2 antibodies are typically raised against specific epitopes, such as the C-terminal region, and validated for specificity using knockout cell lines or siRNA-mediated depletion. Recent studies also focus on NSD2's involvement in drug resistance and its crosstalk with signaling pathways like Wnt and NF-κB, making these antibodies essential for both basic research and therapeutic target validation.