Rabbit Polyclonal XRN1 Antibody

The XRN1 antibody is a crucial reagent used to study the function and expression of XRN1 (5'-3' Exoribonuclease 1), a highly conserved enzyme central to RNA metabolism. XRN1 primarily catalyzes the 5'→3' degradation of uncapped RNAs, playing key roles in mRNA turnover, nonsense-mediated decay (NMD), and processing of non-coding RNAs. It is essential for maintaining RNA homeostasis, regulating gene expression, and eliminating defective transcripts. In eukaryotes, XRN1 is implicated in diverse processes, including antiviral defense, miRNA-mediated silencing, and developmental signaling. Dysregulation of XRN1 has been linked to cancers, neurological disorders, and viral infections. Antibodies targeting XRN1 enable researchers to investigate its localization, expression levels, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. These tools have been instrumental in elucidating XRN1's role in stress granule dynamics, viral RNA clearance, and its interplay with decapping enzymes. Commercially available XRN1 antibodies are typically raised against specific epitopes of human or model organism-derived proteins, validated for species cross-reactivity and application-specific performance. Recent studies also explore XRN1's non-catalytic functions in transcription regulation, expanding its biological significance beyond RNA degradation.