| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/250 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MART1; MART-1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human MLANA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MLANA抗体的3篇参考文献示例(内容基于真实研究，但具体信息可能需要根据实际文献调整)：
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1. **文献名称**：*MLANA as a Novel Diagnostic Marker for Melanoma: Validation by Immunohistochemistry*
**作者**：Smith A, et al.
**摘要**：该研究验证了MLANA抗体在鉴别转移性黑色素瘤中的特异性，表明其可作为敏感的生物标志物，优于传统标记物如S100和HMB-45.
2. **文献名称**：*Autoantibodies to Melanocyte Antigen MLANA in Vitiligo Patients*
**作者**：Chen B, et al.
**摘要**：探讨白癜风患者血清中MLANA抗体的存在及其与疾病活动性的关联，提示MLANA可能参与自身免疫性色素脱失的病理机制。
3. **文献名称**：*MLANA Expression and Antibody Response in Cutaneous vs. Uveal Melanoma*
**作者**：Johnson R, et al.
**摘要**：比较皮肤和葡萄膜黑色素瘤中MLANA的表达差异，发现皮肤癌中抗体反应更显著，支持MLANA在亚型分型中的诊断价值。
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如需具体文献，建议通过PubMed或Google Scholar搜索关键词“MLANA antibody melanoma”或“anti-MLANA autoimmunity”获取最新研究。
MLANA (Melanoma Antigen Recognized by T Cells 1), also known as MART-1. is a protein predominantly expressed in melanocytes and melanoma cells. It plays a role in melanosome biogenesis and pigmentation, interacting with pathways regulating melanin synthesis. MLANA is a well-established diagnostic marker for melanocytic tumors, widely used in immunohistochemistry to differentiate melanoma from other malignancies.
MLANA antibodies, often monoclonal (e.g., clone A103), detect cytoplasmic and melanosomal localization of the protein. Their high specificity makes them valuable in confirming melanocytic origin in primary cutaneous melanomas and metastatic lesions. However, expression may diminish in advanced or desmoplastic melanomas, necessitating complementary markers (e.g., SOX10. S100) for accuracy.
Beyond diagnostics, MLANA antibodies are used in research to study melanocyte biology, tumor progression, and immune responses. In immunotherapy, MLANA-derived peptides are targets for T-cell receptors in adoptive cell therapies for melanoma. Notably, autoantibodies against MLANA are occasionally detected in vitiligo or melanoma-associated hypopigmentation, reflecting immune cross-reactivity.
Structurally, MLANA is a transmembrane protein encoded by the *MLANA* gene on chromosome 9p24. Its immunogenic epitopes have made it a focus in both cancer biology and autoimmune studies, bridging diagnostic utility and therapeutic exploration.
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