| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HOX3; cp19; HOX3E |
| WB Predicted band size | 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXC4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及HOXC4抗体的代表性文献(信息为模拟示例，实际文献需通过数据库核实)：
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1. **文献名称**: *HOXC4 regulates self-renewal in embryonic stem cells through Wnt/β-catenin signaling*
**作者**: Li Y, et al.
**摘要**: 本研究利用HOXC4特异性抗体通过染色质免疫沉淀(ChIP)和免疫荧光技术，揭示了HOXC4通过调控Wnt通路关键基因表达维持胚胎干细胞多能性的机制。
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2. **文献名称**: *Antibody validation of HOXC4 in human colorectal cancer tissues*
**作者**: Smith J, Patel R.
**摘要**: 文章报道了一种新型HOXC4单克隆抗体的开发与验证，通过Western blot和免疫组化证实其在结直肠癌组织中特异性识别HOXC4蛋白，并发现其高表达与患者不良预后相关。
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3. **文献名称**: *HOXC4 modulates B-cell differentiation: Insights from knockout models and antibody-based detection*
**作者**: Garcia M, et al.
**摘要**: 研究通过HOXC4抗体进行流式细胞术和免疫印迹分析，证明HOXC4缺失导致B细胞分化异常，提示其在免疫系统中的潜在调控作用。
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如需具体文献，建议通过PubMed或Google Scholar搜索关键词“HOXC4 antibody + application/validation”获取最新研究。
The HOXC4 antibody is a tool used to detect and study the HOXC4 protein, a member of the homeobox (HOX) gene family. HOX genes encode transcription factors critical for regulating body axis patterning, cell differentiation, and organogenesis during embryonic development. Specifically, HOXC4 is part of the HOXC cluster located on chromosome 12 and is involved in anterior-posterior axis specification. It plays roles in hematopoietic, neural, and urogenital system development, as well as cellular proliferation and differentiation. Dysregulation of HOXC4 has been linked to cancers, including leukemia and breast cancer, where its aberrant expression may drive tumor progression or metastasis.
HOXC4 antibodies are widely used in research to investigate protein expression, localization, and function in both normal and diseased tissues. They enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to visualize HOXC4 in cells or tissue sections. Additionally, these antibodies support chromatin immunoprecipitation (ChIP) assays to study HOXC4’s DNA-binding activity and regulatory targets. Commercially available HOXC4 antibodies are typically validated for specificity, often targeting conserved regions of the protein, such as the homeodomain. Researchers use them to explore HOXC4’s role in developmental pathways, its interaction with signaling molecules, and its potential as a biomarker or therapeutic target in malignancies. Proper controls, such as knockout cell lines, are essential to confirm antibody specificity in experimental setups.
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