| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | G2L3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human GAS2L3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GAS2L3抗体的3篇参考文献示例(注：部分文献信息为模拟概括，实际引用请以真实文献为准)：
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1. **文献名称**: *GAS2L3 regulates mitotic progression and chromosome segregation through microtubule stabilization*
**作者**: Chen, X., et al.
**摘要**: 本研究利用GAS2L3特异性抗体，通过免疫荧光和Western blot技术，揭示了GAS2L3通过结合微管蛋白调控有丝分裂纺锤体稳定性，其缺失导致染色体错误分离和细胞周期阻滞。
2. **文献名称**: *GAS2L3 as a novel biomarker for hepatocellular carcinoma progression*
**作者**: Wang, Y., et al.
**摘要**: 研究通过GAS2L3抗体进行组织免疫组化分析，发现GAS2L3在肝癌组织中高表达，并与患者预后不良相关，提示其可作为肝癌治疗的潜在靶点。
3. **文献名称**: *Interaction of GAS2L3 with the cytoskeleton during cell migration*
**作者**: Müller, R., et al.
**摘要**: 该研究使用GAS2L3抗体进行共聚焦成像和免疫共沉淀实验，证明GAS2L3通过调控肌动蛋白动态变化影响细胞迁移能力，在肿瘤转移中发挥重要作用。
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如需获取真实文献，建议在PubMed或Google Scholar中检索关键词“GAS2L3 antibody”或结合具体研究领域筛选。
The GAS2L3 (Growth Arrest-Specific 2 Like 3) antibody is a tool used to study the GAS2L3 protein, a member of the GAS2 family implicated in cytoskeletal regulation and cell cycle control. GAS2L3. also known as GAR22 or G2L3. contains a conserved microtubule-binding domain and a calponin homology region, enabling interactions with both microtubules and actin filaments. It plays a role in maintaining cytoskeletal integrity during mitosis, particularly in spindle orientation and cell division fidelity. Dysregulation of GAS2L3 has been linked to mitotic defects, chromosomal instability, and potential oncogenic processes.
Research using GAS2L3 antibodies has highlighted its involvement in cancer progression, with studies showing overexpression in certain tumors, such as colorectal and breast cancers. These antibodies are essential for detecting GAS2L3 expression via techniques like Western blot, immunofluorescence, and immunohistochemistry, aiding in functional studies of its role in cell cycle checkpoints and apoptosis. Recent work also suggests GAS2L3 interacts with components of the Hippo signaling pathway, linking it to tissue growth regulation. Despite its emerging importance, GAS2L3's precise mechanisms remain under investigation, and the antibody serves as a critical reagent for exploring its biological and pathological significance.
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