| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MDGI; FABP11; H-FABP; M-FABP; O-FABP |
| WB Predicted band size | 15 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human FABP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FABP3抗体的3篇参考文献的简要信息：
**1. 文献名称**：*"Fatty acid-binding protein 3 as a biomarker of myocardial ischemia-reperfusion injury"*
**作者**：Wang G, et al.
**摘要**：该研究利用FABP3抗体检测心肌缺血再灌注损伤模型中的FABP3表达水平，发现FABP3在损伤后显著升高，提示其可作为心脏损伤的生物标志物，并探讨了其与细胞凋亡的关系。
**2. 文献名称**：*"FABP3 in neurodegenerative diseases: A potential therapeutic target?"*
**作者**：Smith J, et al.
**摘要**：通过免疫组化和Western blot分析，研究使用FABP3抗体揭示了其在阿尔茨海默病和帕金森病患者脑组织中的异常聚集，提示FABP3可能参与神经退行性病变的脂质代谢失调机制。
**3. 文献名称**：*"Development and validation of a monoclonal antibody specific for human FABP3"*
**作者**：Li X, et al.
**摘要**：该文献报道了一种高特异性FABP3单克隆抗体的开发，验证了其在ELISA、免疫荧光和流式细胞术中的应用，并证明其可用于检测多种癌症中FABP3的过表达。
**4. 文献名称**：*"FABP3 as a mediator of lipid-induced apoptosis in cardiomyocytes"*
**作者**：Tanaka K, et al.
**摘要**：研究通过FABP3抗体抑制实验，发现FABP3在心肌细胞脂毒性应激中促进线粒体途径凋亡，揭示了其在心脏代谢疾病中的潜在病理作用。
以上文献涵盖了FABP3抗体在心血管疾病、神经退行性疾病、癌症及抗体开发中的关键应用。
Fatty acid-binding protein 3 (FABP3), also known as heart-type FABP (H-FABP), is a small cytoplasmic protein primarily expressed in cardiac and skeletal muscle, as well as in specific brain regions. It belongs to the FABP family, which facilitates intracellular transport of fatty acids and regulates lipid metabolism, signaling, and gene expression. FABP3 plays a critical role in energy homeostasis by binding long-chain fatty acids and shuttling them to mitochondria for β-oxidation.
FABP3 has gained attention as a biomarker for myocardial injury, as it is rapidly released into circulation during cardiac ischemia. Additionally, it is implicated in neurodegenerative diseases, including Alzheimer’s and Parkinson’s, due to its involvement in neuronal lipid metabolism and synaptic dysfunction. In cancer, altered FABP3 expression has been linked to tumor progression and metastasis.
FABP3 antibodies are essential tools for detecting and quantifying the protein in research and diagnostics. They are widely employed in techniques like Western blotting, immunohistochemistry (IHC), and ELISA to study FABP3's expression patterns, subcellular localization, and interactions in both physiological and pathological contexts. Commercial FABP3 antibodies are typically raised against conserved epitopes, with validation in specific applications and species. Researchers must select antibodies based on target isoforms, cross-reactivity, and compatibility with assay conditions. Recent studies also utilize FABP3 antibodies to explore its dual role in lipid regulation and disease mechanisms, highlighting its therapeutic potential.
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