| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | VHR |
| WB Predicted band size | 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human DUSP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇关于DUSP3抗体的参考文献摘要(内容基于公开研究整理，非真实文献，仅作示例)：
---
1. **文献名称**: "DUSP3 regulates ERK/MAPK signaling in colorectal cancer via phosphatase activity"
**作者**: Smith A, et al.
**摘要**: 本研究利用DUSP3特异性抗体，通过Western blot和免疫组化分析结直肠癌组织中DUSP3的表达，发现其通过去磷酸化ERK蛋白抑制肿瘤生长，提示DUSP3可能作为癌症治疗的潜在靶点。
2. **文献名称**: "DUSP3 modulates innate immune response by dephosphorylating STAT1 in macrophages"
**作者**: Lee H, et al.
**摘要**: 文章使用DUSP3抗体进行免疫共沉淀实验，证实DUSP3通过调控STAT1的磷酸化水平影响巨噬细胞炎症因子分泌，揭示了其在免疫应答中的关键作用。
3. **文献名称**: "Functional characterization of DUSP3 in endothelial cell migration and angiogenesis"
**作者**: Chen L, et al.
**摘要**: 通过siRNA敲低和DUSP3抗体标记技术，研究发现DUSP3通过调控VEGFR2信号通路影响内皮细胞迁移，为抗血管生成治疗提供了新机制。
---
如需查找真实文献，建议在PubMed或Google Scholar搜索关键词：**DUSP3 antibody**, **DUSP3 phosphatase**, 或结合具体研究领域(如癌症、免疫、信号通路)。
DUSP3 (Dual Specificity Phosphatase 3), also known as Vaccinia H1-related phosphatase (VHR), is a member of the dual-specificity phosphatase family. It regulates mitogen-activated protein kinase (MAPK) signaling pathways by dephosphorylating critical tyrosine and threonine residues on ERK, JNK, and p38 kinases. DUSP3 plays a role in cellular processes such as proliferation, differentiation, and apoptosis, with implications in cancer, immune responses, and angiogenesis. Studies suggest it may act as both tumor suppressor and promoter depending on context, highlighting its complex regulatory functions.
DUSP3 antibodies are essential tools for detecting and quantifying DUSP3 protein expression in research. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study its localization, expression patterns, and interactions in various tissues and disease models. High-quality DUSP3 antibodies exhibit specificity for distinct isoforms and phosphorylation states, enabling precise investigation of its activity. Recent research has linked DUSP3 dysregulation to diseases such as breast cancer, leukemia, and inflammatory disorders, driving demand for reliable antibodies to explore its therapeutic potential. Validation using knockout controls or siRNA is critical to ensure antibody specificity in experimental settings.
×
