| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HOX2; HOX2C; HHO.C1; Hox-2.3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human HOXB7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于HOXB7抗体的参考文献示例(内容为模拟虚构，仅供参考)：
1. **文献名称**：*HOXB7 Expression Promotes Tumor Progression in Triple-Negative Breast Cancer*
**作者**：Smith A, et al.
**摘要**：研究利用HOXB7特异性抗体检测发现，HOXB7在三阴性乳腺癌中显著高表达，并通过激活EGFR信号通路促进肿瘤细胞侵袭和转移。
2. **文献名称**：*HOXB7 as a Prognostic Marker in Cutaneous Melanoma*
**作者**：Chen L, et al.
**摘要**：通过免疫组化(HOXB7抗体染色)分析显示，HOXB7高表达与黑色素瘤患者生存率降低显著相关，提示其可作为预后不良的生物标志物。
3. **文献名称**：*HOXB7 Regulates Angiogenesis via VEGF in Colorectal Cancer*
**作者**：Wang X, et al.
**摘要**：研究使用HOXB7抗体阻断实验证明，HOXB7通过上调VEGF表达促进结直肠癌血管生成，靶向HOXB7可抑制肿瘤生长。
4. **文献名称**：*HOXB7 Antibody-Based Therapeutic Strategy in Pancreatic Cancer*
**作者**：Kim H, et al.
**摘要**：开发了一种新型HOXB7单克隆抗体，体外实验显示其能特异性结合HOXB7蛋白并抑制胰腺癌细胞增殖，为靶向治疗提供潜在方案。
(注：以上文献为示例，实际文献需通过PubMed、Web of Science等数据库检索。)
**Background of HOXB7 Antibody**
HOXB7. a member of the homeobox (HOX) gene family, encodes a transcription factor critical in embryonic development, cell differentiation, and tissue patterning. HOX proteins regulate gene expression by binding to DNA via their conserved homeodomain, influencing processes like proliferation, apoptosis, and migration. HOXB7. specifically, has been implicated in oncogenesis, with studies linking its overexpression to tumor progression in cancers such as breast, ovarian, melanoma, and leukemia. It promotes angiogenesis, metastasis, and chemoresistance by modulating pathways like ERK and Wnt/β-catenin.
HOXB7 antibodies are essential tools for detecting and quantifying HOXB7 protein levels in research and diagnostics. These antibodies enable techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study HOXB7's expression patterns, subcellular localization, and interactions in normal vs. diseased tissues. Commercially available HOXB7 antibodies are typically raised against specific epitopes, such as recombinant protein fragments or synthetic peptides, and validated for specificity and sensitivity.
Research using HOXB7 antibodies has highlighted its role as a potential biomarker or therapeutic target in cancer. For instance, elevated HOXB7 correlates with poor prognosis in breast cancer, suggesting its utility in risk stratification. Ongoing studies explore HOXB7 inhibition to disrupt oncogenic signaling, underscoring the antibody's importance in both mechanistic and translational contexts.
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