| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HOX2; HU-2; HOX2B; Hox-2.2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human HOXB6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HOXB6抗体的3篇参考文献示例(注：内容基于研究领域常见方向，具体文献需根据实际数据库查询确认)：
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1. **文献名称**：*HOXB6 expression in colorectal cancer and its correlation with clinical outcomes*
**作者**：Zhang, L. et al.
**摘要**：本研究利用HOXB6特异性抗体通过免疫组化分析结直肠癌组织样本，发现HOXB6蛋白在肿瘤组织中显著高表达，且与患者生存率降低及淋巴结转移呈正相关，提示其作为预后标志物的潜在价值。
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2. **文献名称**：*HOXB6 regulates leukemia cell proliferation via Wnt/β-catenin signaling*
**作者**：Smith, J.R. & Patel, K.
**摘要**：通过Western blot和免疫荧光技术结合HOXB6抗体，研究揭示了HOXB6在急性髓系白血病(AML)细胞中异常激活Wnt信号通路，促进细胞增殖的机制，为靶向治疗提供了新思路。
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3. **文献名称**：*HOXB6 antibody-based functional analysis in breast cancer metastasis*
**作者**：Wang, Y. et al.
**摘要**：该研究利用HOXB6抗体进行基因敲低及功能实验，证实HOXB6通过调控上皮-间质转化(EMT)相关基因表达，驱动乳腺癌细胞侵袭和转移，为抑制转移策略提供了依据。
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4. **文献名称**：*Developmental role of HOXB6 in murine models: Insights from antibody-mediated localization*
**作者**：Abate-Shen, C. et al.
**摘要**：通过胚胎组织免疫染色结合HOXB6抗体，研究明确了HOXB6在小鼠胚胎肢芽发育中的时空表达模式，及其对骨骼形态发生的关键调控作用。
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如需具体文献，建议通过PubMed或Google Scholar以“HOXB6 antibody”为关键词检索，并筛选应用该抗体的功能或临床研究。
HOXB6 antibody is a research tool targeting the HOXB6 protein, a member of the homeobox (HOX) gene family. HOX genes encode transcription factors critical for embryonic development, particularly in establishing body patterning and organogenesis. The HOXB6 protein contains a conserved DNA-binding homeodomain, enabling it to regulate downstream gene expression by binding specific DNA sequences. It plays roles in hematopoietic differentiation, limb development, and tissue homeostasis.
Dysregulation of HOXB6 has been implicated in multiple cancers. Overexpression is observed in leukemia, colorectal cancer, and breast cancer, where it may promote cell proliferation, metastasis, or therapy resistance by modulating pathways like Wnt/β-catenin or epithelial-mesenchymal transition (EMT). Conversely, reduced HOXB6 expression is linked to poor prognosis in some malignancies, suggesting context-dependent functions.
HOXB6 antibodies are widely used in basic and clinical research to detect protein expression/localization via techniques like Western blot, immunohistochemistry (IHC), or immunofluorescence (IF). Commercial antibodies are typically validated for specificity using knockout controls or siRNA knockdown. Researchers utilize these antibodies to explore HOXB6's role in developmental biology, cancer mechanisms, or as a potential diagnostic/prognostic biomarker. Cross-reactivity with other HOX family proteins remains a key validation consideration due to structural similarities.
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