关键信息
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基因名
KPNB1
- 应用
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别名
Karyopherin subunit beta-1Nuclear factor p97Pore targeting complex 97KDA subunit ;PTAC97SCG
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种属
Mouse
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P70168
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表达区间
1-876aa
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分子量
101.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
KPNB1, or importin beta 1, is a crucial protein involved in the nuclear transport pathway, specifically functioning as a karyopherin that facilitates the translocation of proteins into the nucleus. Its role in regulating nuclear-cytoplasmic transport has made KPNB1 a significant focus of research, particularly in the context of cellular processes such as gene expression, cell cycle regulation, and response to stress. Abnormalities in nuclear transport mechanisms, including those involving KPNB1, have been implicated in various diseases, including cancer, neurodegenerative disorders, and viral infections. The study of KPNB1 is further propelled by its interactions with a range of proteins, influencing cellular signaling pathways and impacting cellular localization. Recombinant KPNB1 protein is often produced for experimental applications, allowing researchers to investigate its structure, function, and interactions in detail. By understanding KPNB1's mechanisms in healthy and diseased states, scientists aim to uncover potential therapeutic targets that could be instrumental in developing novel treatments for diseases associated with impaired nuclear transport. Overall, KPNB1 serves as a key player in cellular homeostasis, and the characterization of its recombinant protein can provide valuable insights into the fundamental processes of cell biology and pathology.
