| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | mGlu4; GPRC1D; MGLUR4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GRM4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GRM4抗体的3篇参考文献概览(文献名称、作者及摘要简述)：
1. **"Characterization of a Novel GRM4 Antibody for Immunohistochemical Detection in Brain Tissue"**
- **作者**: Smith A, et al.
- **摘要**: 开发并验证了一种高特异性GRM4抗体，通过免疫组化分析证实其在啮齿类及人类脑组织中的表达定位，尤其在海马和皮层神经元中显著，支持其在神经通路研究中的应用。
2. **"GRM4 Receptor Expression in Parkinson’s Disease Models: Insights from Antibody-Based Profiling"**
- **作者**: Chen L, et al.
- **摘要**: 利用GRM4抗体研究帕金森病模型中受体表达变化，发现纹状体区域GRM4水平降低可能与多巴胺能神经元退行性变相关，提示其作为疾病生物标志物的潜力。
3. **"Antibody Validation for Western Blot Analysis of GRM4 in Cancer Cell Lines"**
- **作者**: Tanaka K, et al.
- **摘要**: 通过Western blot和siRNA敲除实验验证某商业GRM4抗体的特异性，确认其在多种癌细胞系中检测到约100 kDa的单一条带，为癌症中代谢型谷氨酸受体功能研究提供可靠工具。
(注：以上为模拟文献，实际引用需以真实论文为准。)
The GRM4 antibody is a research tool designed to detect and analyze the metabotropic glutamate receptor 4 (mGluR4), encoded by the GRM4 gene. As a member of the G protein-coupled receptor (GPCR) family, mGluR4 plays a critical role in modulating synaptic transmission and neuronal excitability by responding to glutamate, the primary excitatory neurotransmitter in the central nervous system. GRM4 receptors are predominantly expressed in presynaptic terminals, where they inhibit neurotransmitter release via downstream signaling pathways, contributing to synaptic plasticity and neuroprotection. Dysregulation of GRM4 has been implicated in neurological and psychiatric disorders, including Parkinson’s disease, anxiety, and schizophrenia, making it a target for therapeutic exploration.
The GRM4 antibody is widely used in neuroscience research to study receptor localization, expression levels, and functional interactions in both physiological and pathological contexts. It enables techniques such as Western blotting, immunohistochemistry, and immunofluorescence to visualize receptor distribution in tissues or cultured cells. Validated antibodies are essential for ensuring specificity, particularly given the structural similarities among mGluR subtypes. Recent studies utilizing GRM4 antibodies have advanced understanding of its role in modulating cAMP and calcium signaling, as well as its potential as a drug target for neurological disorders. Continued development of high-affinity, selective GRM4 antibodies remains vital for unraveling its complex roles in brain function and disease mechanisms.
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