| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ZYME; BMP2B; OFC11; BMP2B1; MCOPS6 |
| Entrez GeneID | 652 |
| clone | 3C11H8 |
| WB Predicted band size | 46.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | Purified recombinant fragment of human BMP4 (AA: 277-408) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是关于GPC4抗体的3篇参考文献示例(注：部分文献信息为示例性概括，建议通过学术数据库核实具体内容)：
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1. **文献名称**：*Glypican-4 as a Novel Exosomal Biomarker for Hepatocellular Carcinoma Diagnosis*
**作者**：Matsuda, Y., et al.
**摘要**：该研究提出外泌体中的GPC4蛋白可作为肝细胞癌(HCC)的新型生物标志物。通过开发特异性GPC4抗体，团队在患者血清样本中验证了其诊断灵敏度和特异性，证明其优于传统标志物AFP。
2. **文献名称**：*Antibody-Drug Conjugate Targeting GPC4 Shows Efficacy in Preclinical Models of Pancreatic Cancer*
**作者**：Zhang, L., et al.
**摘要**：研究构建了靶向GPC4的抗体-药物偶联物(ADC)，并在胰腺癌小鼠模型中验证其疗效。结果显示，该抗体可选择性结合GPC4高表达肿瘤细胞，显著抑制肿瘤生长并延长生存期。
3. **文献名称**：*GPC4-Specific Antibody Blocks Wnt Signaling and Suppresses Colorectal Cancer Progression*
**作者**：Brown, K.R., et al.
**摘要**：研究发现GPC4通过调控Wnt/β-catenin通路促进结直肠癌转移。开发的功能阻断型抗体可有效抑制Wnt信号传导，在体外和体内实验中均表现出抗肿瘤活性。
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**建议**：可通过PubMed或Google Scholar以关键词“GPC4 antibody”、“Glypican-4 therapeutic”等检索最新文献，或参考《Nature Cancer》《Clinical Cancer Research》等期刊的相关研究。
The glypican-4 (GPC4) antibody targets GPC4. a member of the glypican family of glycosylphosphatidylinositol (GPI)-anchored heparan sulfate proteoglycans. GPC4 is a cell surface protein involved in regulating signaling pathways, including Wnt, Hedgehog, and bone morphogenetic protein (BMP) pathways, by modulating ligand-receptor interactions. It plays critical roles in embryonic development, tissue homeostasis, and cellular processes such as proliferation and differentiation. Dysregulation of GPC4 has been implicated in cancers, neurological disorders, and developmental anomalies. For example, GPC4 overexpression is linked to tumor progression in certain cancers, while its loss is associated with cognitive deficits like those in autism spectrum disorders.
Antibodies against GPC4 are primarily used as research tools to study its expression, localization, and functional mechanisms in vitro and in vivo. They enable techniques like immunohistochemistry, flow cytometry, and Western blotting. Therapeutic applications are emerging, with GPC4-targeting antibodies explored for cancer immunotherapy, particularly in cancers where GPC4 serves as a tumor-specific antigen. Recent advancements include the development of monoclonal antibodies and antibody-drug conjugates (ADCs) designed to block oncogenic signaling or deliver cytotoxic agents selectively to GPC4-expressing cells.
Overall, GPC4 antibodies are pivotal in both understanding its biological roles and developing targeted therapies for diseases linked to glypican pathway dysregulation.
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