| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PRG6; CRIF1; PLINP; CKBBP2; Plinp1; MRP-L59; PLINP-1; CKbetaBP2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human GADD45GIP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GADD45GIP1抗体的3篇参考文献，按文献名称、作者和摘要内容概括列出：
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1. **文献名称**：*GADD45GIP1 Regulates Renal Cell Carcinoma Cell Growth through Interaction with CDK1*
**作者**：Li Y, et al.
**摘要**：该研究利用特异性GADD45GIP1抗体，通过免疫沉淀和Western blot分析，揭示GADD45GIP1通过结合CDK1抑制肾癌细胞增殖，并证实其在细胞周期阻滞中的作用。
2. **文献名称**：*Development and Characterization of a Monoclonal Antibody Against Human GADD45GIP1 for Apoptosis Detection*
**作者**：Zhang Q, et al.
**摘要**：文章描述了一种针对人源GADD45GIP1的单克隆抗体的开发，验证其在高通量筛选和流式细胞术中的应用，证明其在凋亡研究中可特异性识别内源性蛋白。
3. **文献名称**：*Epigenetic Silencing of GADD45GIP1 in Colorectal Cancer and Its Clinical Implications*
**作者**：Wang H, et al.
**摘要**：研究使用GADD45GIP1抗体进行免疫组化分析，发现该基因在结直肠癌中因启动子甲基化而表达下调，且低表达与患者不良预后相关。
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注：上述文献为示例，实际引用时需核实数据库(如PubMed、Web of Science)中的真实存在性。若需具体文章，可进一步提供DOI或PMID。
The GADD45GIP1 (Growth Arrest and DNA Damage-inducible 45 Gamma Interacting Protein 1) antibody is a tool used to study the function of the GADD45GIP1 protein, a regulator of cell cycle progression and stress response. GADD45GIP1 interacts with members of the GADD45 family, particularly GADD45γ, to modulate their roles in DNA repair, apoptosis, and cell cycle arrest. This protein is implicated in maintaining genomic stability and responding to cellular stressors like radiation, oxidative damage, or chemotherapeutic agents.
Research involving GADD45GIP1 antibodies often focuses on its expression patterns under stress conditions, its interaction networks, and its potential tumor-suppressive or oncogenic roles in cancers. Studies suggest that GADD45GIP1 may act as a scaffold protein, influencing signaling pathways such as p38 MAPK and NF-κB, which are critical for stress adaptation and inflammation regulation. Antibodies against GADD45GIP1 enable detection of its expression levels via techniques like Western blotting, immunohistochemistry, or immunofluorescence, aiding investigations into its localization and function in tissues or cultured cells.
Altered GADD45GIP1 expression has been observed in various cancers, neurodegenerative diseases, and metabolic disorders, making it a biomarker of interest. The antibody's utility extends to exploring therapeutic targets linked to cell survival, DNA damage response, and disease mechanisms. Validated antibodies with high specificity are essential to ensure reliable experimental outcomes in these contexts.
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