Rabbit Polyclonal DOK6 Antibody

The DOK6 (Docking Protein 6) antibody is a tool used to study the DOK6 protein, a member of the DOK family of adaptor proteins involved in intracellular signaling. DOK proteins typically act as scaffolds, mediating interactions between tyrosine kinase receptors and downstream effectors. DOK6. specifically, is prominently expressed in the nervous system and has been implicated in neurodevelopment and neuronal differentiation. It interacts with receptor tyrosine kinases, such as Trk receptors, to regulate signaling pathways critical for axon guidance, synaptic plasticity, and neuronal survival. Structurally, DOK6 contains conserved domains, including a pleckstrin homology (PH) domain and phosphotyrosine-binding (PTB) domain, which facilitate protein-protein interactions and membrane localization. Research using DOK6 antibodies has helped elucidate its role in neural circuit formation and its potential association with neurological disorders or cancers. These antibodies are commonly employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect DOK6 expression and localization in tissues or cell lines. Ongoing studies aim to clarify DOK6's regulatory mechanisms and its broader functional significance beyond the nervous system.