WB | 咨询技术 | Human,Mouse,Rat |
IF | 咨询技术 | Human,Mouse,Rat |
IHC | 1/25-1/100 | Human,Mouse,Rat |
ICC | 技术咨询 | Human,Mouse,Rat |
FCM | 咨询技术 | Human,Mouse,Rat |
Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
Aliases | yt14r; SYT14L; syt14r; Strep14; CHR14SYT |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse |
Immunogen | Synthetic peptide of human SYT16 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SYT16抗体的3篇模拟参考文献示例(注:因SYT16研究较为小众,以下内容为假设性概括,建议通过PubMed或专业数据库查询真实文献):
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1. **文献名称**: *Synaptotagmin XVI (SYT16) regulates exocytosis in neuroendocrine cells through calcium-dependent interactions*
**作者**: Chen L, et al.
**摘要**: 本研究利用SYT16特异性抗体,揭示了SYT16在神经内分泌细胞胞吐作用中的功能。通过免疫沉淀和Western blot分析,发现SYT16通过其C2结构域与钙离子结合,调控囊泡与细胞膜的融合过程。
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2. **文献名称**: *Developmental expression of SYT16 in the mammalian brain and its role in synaptic plasticity*
**作者**: Rodriguez S, et al.
**摘要**: 通过免疫组化结合SYT16抗体,作者发现SYT16在小鼠大脑发育早期高表达,尤其在皮层和海马区。基因敲除实验表明,SYT16缺失导致突触可塑性受损,提示其参与学习记忆相关通路。
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3. **文献名称**: *SYT16 antibody-based profiling identifies its overexpression in pancreatic cancer progression*
**作者**: Kim H, et al.
**摘要**: 研究利用商业化SYT16单克隆抗体,在胰腺癌组织芯片中检测到SYT16蛋白异常高表达,并与患者预后不良相关。体外实验证实SYT16通过调控EGFR信号通路促进肿瘤侵袭。
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如需真实文献,建议在**PubMed**中搜索关键词“SYT16 antibody”或“Synaptotagmin 16”,并筛选近5年的功能研究或抗体应用类论文。
The SYT16 antibody targets Synaptotagmin 16 (SYT16), a member of the synaptotagmin family of membrane-trafficking proteins. SYT16 is characterized by its N-terminal transmembrane domain and C-terminal tandem C2 domains, which are implicated in calcium-dependent membrane interactions. While the functional roles of SYT16 remain less defined compared to well-studied isoforms like SYT1 (critical for synaptic vesicle exocytosis), emerging research suggests its involvement in secretory pathways, particularly in non-neuronal tissues. SYT16 is expressed in the brain, pancreas, and other organs, with studies linking it to Golgi-associated vesicle transport, hormone secretion, and cellular stress responses. Its potential role in diseases, such as cancer or neurological disorders, is under investigation, though mechanistic insights are limited.
SYT16 antibodies are primarily used as research tools to detect protein expression, localization, and interaction partners via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercial SYT16 antibodies are often developed in rabbits or mice, with validation in specific cell lines or tissues. However, users should verify antibody specificity due to possible cross-reactivity with other synaptotagmins or isoforms. Recent studies utilizing SYT16 antibodies have explored its regulatory effects on secretion in pancreatic β-cells and its dysregulation in tumors, highlighting its emerging relevance in cellular physiology and pathology.
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