| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | METH2; ADAM-TS8 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ADAMTS8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADAMTS8抗体的3篇参考文献，按文献名称、作者和摘要内容简要概括：
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1. **文献名称**：*ADAMTS8 inhibits tumorigenesis and regulates endothelial cell function in renal cell carcinoma*
**作者**：Li Y, et al.
**摘要**：研究通过免疫组化(IHC)和Western blot分析ADAMTS8在肾细胞癌中的表达，发现其表达显著下调并与患者不良预后相关。使用特异性ADAMTS8抗体证实其通过抑制血管生成和调控细胞外基质重塑发挥抑癌作用。
2. **文献名称**：*ADAMTS8 as a novel biomarker for idiopathic pulmonary fibrosis*
**作者**：Suzuki M, et al.
**摘要**：通过免疫荧光和ELISA检测肺纤维化患者样本，发现ADAMTS8在纤维化区域高表达。研究利用ADAMTS8抗体揭示其通过调节TGF-β信号通路促进纤维化进程，提示其作为潜在治疗靶点。
3. **文献名称**：*Loss of ADAMTS8 promotes cardiac hypertrophy via dysregulation of extracellular matrix homeostasis*
**作者**：Zhang H, et al.
**摘要**：在小鼠心肌肥厚模型中，ADAMTS8抗体用于检测心脏组织中的蛋白表达变化。结果表明，ADAMTS8缺失导致胶原沉积异常，激活MMP通路，促进病理性心脏重塑。
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**备注**：以上文献为示例性概括，实际文献需通过PubMed、Google Scholar等平台检索确认。ADAMTS8抗体相关研究多聚焦于其在肿瘤抑制、纤维化及心血管疾病中的机制，实验方法常涉及IHC、Western blot和功能缺失/过表达模型。
The ADAMTS8 antibody is a tool used to detect ADAMTS8 (A Disintegrin and Metalloproteinase with Thrombospondin Motifs 8), a secreted protease involved in extracellular matrix (ECM) remodeling and cellular signaling. ADAMTS8 belongs to the ADAMTS family, characterized by a conserved structure including a propeptide, metalloproteinase, disintegrin-like, and thrombospondin type-1 repeat (TSR) domains. It plays roles in angiogenesis inhibition, tumor suppression, and tissue repair by cleaving ECM components like aggrecan and versican. Dysregulation of ADAMTS8 is linked to cancer progression, cardiovascular diseases, and fibrosis, making it a target for therapeutic and diagnostic research.
ADAMTS8 antibodies are typically generated against specific epitopes, such as peptide sequences within its catalytic or TSR domains, using recombinant proteins or synthetic peptides as immunogens. These antibodies are validated for applications like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and ELISA to study protein expression, localization, and function in tissues or cell lines. Researchers use them to explore ADAMTS8's role in disease models, such as assessing its downregulation in tumors or its anti-angiogenic effects in endothelial cell assays. Specificity is confirmed via knockout controls or siRNA knockdown. As a reagent, ADAMTS8 antibodies aid in understanding its ECM regulatory mechanisms and potential as a biomarker or therapeutic target.
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