| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HS1-2; LABH2; PHPS1-2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ABHD2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ABHD2抗体的3篇参考文献示例(内容为模拟概括，建议查阅实际数据库获取真实文献)：
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1. **文献名称**：ABHD2 Controls Sperm Cell Membrane Remodeling and Protease Signaling During Fertilization
**作者**：Miller MR, et al.
**摘要**：该研究揭示了ABHD2蛋白在精子激活中的关键作用，通过其水解酶活性调控细胞膜脂质重组。实验中使用ABHD2抗体进行免疫印迹和免疫荧光定位，证实其在精子头部高表达，并参与孕酮诱导的顶体反应。
2. **文献名称**：ABHD2 as a Novel Biomarker in Non-Small Cell Lung Cancer Progression
**作者**：Chen L, et al.
**摘要**：本研究通过免疫组化及Western blot分析，发现ABHD2在肺癌组织中的表达显著高于正常组织，并与患者预后相关。抗体的特异性验证表明，ABHD2可能通过调节肿瘤微环境中的脂质信号促进转移。
3. **文献名称**：ABHD2 Regulates Lipid Metabolism in Macrophages During Inflammatory Response
**作者**：Santos R, et al.
**摘要**：利用ABHD2抗体敲低实验，研究者发现ABHD2通过水解特定脂类分子调控巨噬细胞的炎症因子分泌，提示其在代谢性疾病中的潜在治疗靶点。
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**注**：以上为示例性内容，实际文献需通过PubMed、Google Scholar等平台以关键词“ABHD2 antibody”或“ABHD2 function”检索，并筛选涉及抗体应用的实验研究。
The ABHD2 (α/β-hydrolase domain-containing protein 2) antibody is a key tool for studying the functional roles of ABHD2. a member of the serine hydrolase superfamily. ABHD2 is a transmembrane protein implicated in lipid metabolism, cell signaling, and reproductive biology. It gained prominence for its critical role in sperm activation, where it acts as a receptor for progesterone, triggering the release of endocannabinoids to induce the acrosome reaction necessary for fertilization (Miller et al., 2016). Beyond reproduction, ABHD2 is linked to cancer progression, inflammation, and lipid regulation, with studies suggesting its involvement in tumor cell migration, invasion, and metastasis through mechanisms like cytoskeletal remodeling.
ABHD2 antibodies, including monoclonal and polyclonal variants, are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect ABHD2 expression and localization in tissues or cultured cells. These antibodies help elucidate its interaction networks, post-translational modifications (e.g., phosphorylation), and tissue-specific expression patterns. Validated antibodies typically target conserved regions, such as the catalytic α/β-hydrolase domain, ensuring cross-reactivity in human, mouse, and rat models. Researchers rely on these antibodies to explore ABHD2’s pathophysiological roles, particularly in infertility, cancer, and metabolic disorders, making them essential for advancing therapeutic and diagnostic strategies.
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