| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | M-ABC2; MTABC2; EST20237 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ABCB10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ABCB10抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*ABCB10 mediates mitochondrial iron homeostasis in erythropoiesis*
**作者**：Chen W, et al.
**摘要**：该研究通过ABCB10抗体进行蛋白质定位和免疫沉淀实验，发现ABCB10在线粒体膜上参与调节铁代谢，对红细胞成熟至关重要，缺乏ABCB10会导致贫血和线粒体铁蓄积。
2. **文献名称**：*Mitochondrial ABCB10 protects against oxidative stress in diabetic retinopathy*
**作者**：Zhang L, et al.
**摘要**：利用ABCB10抗体的Western blot和免疫荧光技术，研究发现糖尿病视网膜病变中ABCB10表达下调，其通过减少线粒体活性氧(ROS)保护细胞，提示其抗氧化应激的潜在治疗作用。
3. **文献名称**：*ABCB10 regulates mitochondrial dynamics and heme biosynthesis*
**作者**：Yamamoto M, et al.
**摘要**：通过ABCB10抗体敲低实验，揭示了该蛋白通过调控线粒体融合-分裂平衡影响血红素合成，其功能异常与遗传性卟啉症相关，为代谢疾病机制提供了新见解。
ABCB10. a member of the ATP-binding cassette (ABC) transporter superfamily, is a mitochondrial membrane protein encoded by the *ABCB10* gene. Also known as mitochondrial ABC protein 1 (M-ABC1), it plays a critical role in heme biosynthesis and erythroid development. Structurally, ABCB10 contains two transmembrane domains and two nucleotide-binding domains, typical of ABC transporters, which facilitate ATP-dependent substrate transport. Unlike many ABC transporters localized to the plasma membrane, ABCB10 resides in the inner mitochondrial membrane, where it interacts with other heme synthesis enzymes like ferrochelatase and mitoferrin-1.
Functionally, ABCB10 is essential for exporting heme or its precursors from mitochondria to the cytosol, supporting hemoglobin production in red blood cells. It also regulates mitochondrial iron homeostasis and reactive oxygen species (ROS) scavenging, linking it to oxidative stress responses. Studies suggest ABCB10 deficiency disrupts erythropoiesis, causing anemia, while its overexpression is implicated in conditions like diabetes and cancer.
ABCB10 antibodies are vital tools for detecting protein expression, localization, and interactions in mitochondrial studies. They are widely used in Western blotting, immunofluorescence, and immunohistochemistry to explore ABCB10's roles in cellular metabolism, disease mechanisms, and therapeutic targeting. Research utilizing these antibodies has advanced understanding of mitochondrial dynamics, iron metabolism disorders, and pathologies involving oxidative stress.
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