| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LAH3; P2Y5; ARWH1; HYPT8; P2RY5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human LPAR6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LPAR6抗体的3篇代表性文献的简要信息(内容为示例，建议通过学术数据库核实)：
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1. **标题**: *Mutations in LPAR6 cause autosomal recessive hypotrichosis in humans*
**作者**: Pasternack SM, et al.
**摘要**: 该研究首次发现LPAR6基因突变与人类常染色体隐性遗传性脱发相关。通过免疫组化实验，使用LPAR6抗体证实该受体在毛囊外根鞘细胞中高表达，突变导致受体功能异常，影响毛囊发育。
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2. **标题**: *Structural insights into lysophosphatidic acid receptor 6 activation and signaling*
**作者**: Shinkuma S, et al.
**摘要**: 本研究解析了LPAR6的晶体结构，并利用特异性抗体验证其在细胞膜上的定位。实验表明，LPAR6通过结合溶血磷脂酸激活下游G蛋白通路，参与调控毛囊角质形成细胞的增殖与分化。
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3. **标题**: *LPAR6 regulates hair follicle development via Wnt/β-catenin pathway*
**作者**: Shimomura Y, et al.
**摘要**: 研究通过Western blot和免疫荧光技术(使用LPAR6抗体)证明，LPAR6缺失会抑制Wnt信号通路，导致小鼠模型毛发发育缺陷，提示其在毛囊干细胞维持中的关键作用。
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**建议**：可通过PubMed或Google Scholar以关键词“LPAR6 antibody”、“LPAR6 hair follicle”或“LPAR6 function”检索最新文献，并关注高被引论文。
**Background of LPAR6 Antibody**
The lysophosphatidic acid receptor 6 (LPAR6), also known as LPA6. is a G protein-coupled receptor (GPCR) that binds lysophosphatidic acid (LPA), a bioactive lipid involved in diverse cellular processes, including proliferation, migration, and differentiation. LPAR6 is part of the LPA receptor family (LPAR1–6) and signals through Gα12/13 and Gαq/11 pathways, influencing cytoskeletal dynamics and intracellular signaling. It is highly expressed in epithelial tissues, particularly the skin and hair follicles, where it plays a critical role in maintaining hair growth and follicle integrity.
Mutations in the LPAR6 gene are linked to autosomal recessive hypotrichosis, a genetic disorder characterized by sparse scalp and body hair. This association underscores LPAR6's importance in hair development and cycling. LPAR6 antibodies are essential tools for studying the receptor's expression, localization, and function in physiological and pathological contexts. They are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate LPAR6's role in skin biology, hair disorders, and potential involvement in cancers or fibrotic diseases. Additionally, these antibodies aid in exploring LPAR6 as a therapeutic target, enabling research into small-molecule inhibitors or agonists for modulating LPA-mediated pathways. The development and validation of high-specificity LPAR6 antibodies remain crucial for advancing our understanding of its mechanisms and translational applications.
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