| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GABRB1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是模拟生成的3篇关于GABRB1抗体的参考文献示例(注：文献信息为假设性示例，实际引用需查询真实数据库)：
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1. **文献名称**: *"Immunolocalization of GABRB1 in the mammalian brain using a novel monoclonal antibody"*
**作者**: Tanaka, K. et al. (2016)
**摘要**: 本研究开发了一种高特异性抗GABRB1单克隆抗体，并通过免疫组化验证了其在啮齿类及人类脑组织中的应用。结果显示GABRB1蛋白在海马体和皮层神经元中高表达，提示其可能参与突触抑制性信号传递。
2. **文献名称**: *"GABRB1 subunit mutations alter receptor pharmacology and contribute to epilepsy pathogenesis"*
**作者**: Zhang, L. et al. (2019)
**摘要**: 通过Western blot和免疫荧光技术，研究者利用商业化GABRB1抗体分析了癫痫患者脑组织中β1亚基的表达水平及亚细胞定位，发现突变导致受体膜表面表达减少，可能与疾病发生相关。
3. **文献名称**: *"Developmental regulation of GABAA receptor β1 subunit expression in the auditory system"*
**作者**: Roberts, M.T. & Fuchs, P.A. (2021)
**摘要**: 该研究使用GABRB1多克隆抗体探究了小鼠听觉系统中β1亚基的发育表达模式，发现其在成熟神经元中的上调表达可能对听觉信号处理至关重要。
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如需真实文献，建议在PubMed或Google Scholar中检索关键词“GABRB1 antibody”、“GABRB1 immunohistochemistry”或“GABAAR β1 subunit”，并筛选应用性研究论文。
The GABRB1 antibody is a research tool designed to target the β1 subunit of the gamma-aminobutyric acid type A (GABA-A) receptor, a major inhibitory neurotransmitter receptor in the central nervous system. GABA-A receptors are ligand-gated ion channels composed of various subunit combinations (e.g., α, β, γ), with the β1 subunit (encoded by the *GABRB1* gene) playing a critical role in receptor assembly, chloride ion channel function, and synaptic inhibition. Antibodies against GABRB1 are utilized to study receptor localization, expression levels, and structural interactions in neurological tissues or cell models.
Research involving GABRB1 antibodies has implications for understanding neurodevelopmental disorders, epilepsy, and anxiety-related conditions, as GABA-A receptor dysfunction is linked to these pathologies. For example, altered β1 subunit expression has been observed in certain epilepsy models and mood disorders. These antibodies are typically validated via techniques like Western blotting, immunohistochemistry, or immunofluorescence to ensure specificity. Challenges include cross-reactivity with other β subunits (β2. β3) due to structural homology, necessitating careful experimental controls. Commercially available GABRB1 antibodies support both basic research and potential diagnostic explorations, though their clinical application remains exploratory. Ongoing studies aim to clarify the subunit-specific mechanisms of GABA-A receptors in health and disease, highlighting the importance of reliable antibody tools.
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