Rabbit Polyclonal GRM2 Antibody

The GRM2 antibody is a crucial tool for studying metabotropic glutamate receptor 2 (mGluR2), a class C G protein-coupled receptor (GPCR) predominantly expressed in the central nervous system. mGluR2 regulates synaptic transmission by inhibiting neurotransmitter release, particularly glutamate and GABA, via Gi/o protein signaling. It plays a role in neuropsychiatric disorders, including anxiety, schizophrenia, and Parkinson’s disease. The GRM2 antibody detects and quantifies mGluR2 expression, aiding research on its localization, function, and interaction with ligands or allosteric modulators. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore receptor distribution in brain regions such as the hippocampus, cortex, and striatum. Studies leveraging this antibody have elucidated mGluR2’s involvement in synaptic plasticity, cognitive processes, and disease mechanisms, supporting drug development targeting mGluR2 for neurological and psychiatric conditions. Validation of GRM2 antibody specificity ensures accurate detection, minimizing cross-reactivity with related receptors like mGluR3. Its application extends to preclinical models, helping evaluate therapeutic candidates that modulate mGluR2 activity to restore glutamatergic signaling imbalances.