| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CYCT2 |
| WB Predicted band size | 81 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CCNT2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CCNT2抗体的3篇示例参考文献(文献为虚构示例，仅供格式参考)：
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1. **文献名称**: *CCNT2 regulates RNA polymerase II activity in human cancer cells*
**作者**: Smith A, et al.
**摘要**: 本研究利用特异性CCNT2抗体通过Western blot和免疫共沉淀(Co-IP)技术，揭示了CCNT2与CDK9的相互作用在多种癌细胞中调控RNA聚合酶II磷酸化的机制，表明CCNT2可能成为癌症治疗的潜在靶点。
2. **文献名称**: *Cyclin T2 antibody-based profiling in HIV-1 latency models*
**作者**: Lee B, et al.
**摘要**: 通过免疫荧光(IF)和高通量测序分析，研究团队使用CCNT2抗体证实了CCNT2在HIV-1潜伏感染T细胞中的表达下调，提示其与病毒转录激活逃逸相关。
3. **文献名称**: *CCNT2 knockout mice exhibit impaired neuronal development*
**作者**: Zhang C, et al.
**摘要**: 利用CCNT2抗体进行组织免疫组化分析，发现CCNT2缺失导致小鼠神经元中RNA聚合酶II停滞，影响突触可塑性和认知功能，揭示了其在神经发育中的关键作用。
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注：以上文献为模拟示例，实际引用时需检索真实数据库(如PubMed)获取权威信息。
The CCNT2 antibody targets cyclin T2. a regulatory protein encoded by the *CCNT2* gene, which belongs to the cyclin family. Cyclins are critical for cell cycle progression and transcriptional regulation by binding to cyclin-dependent kinases (CDKs). CCNT2 specifically partners with CDK9 to form the positive transcription elongation factor b (P-TEFb) complex. This complex phosphorylates RNA polymerase II, enabling transcriptional elongation of target genes, including those involved in stress responses, differentiation, and viral replication (e.g., HIV-1).
CCNT2 is expressed in various tissues and plays roles beyond the cell cycle, such as modulating gene expression in immune cells and neurons. Antibodies against CCNT2 are essential tools for studying its expression, localization, and interactions in both physiological and pathological contexts. They are widely used in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). Research involving CCNT2 antibodies has shed light on its dysregulation in cancers, neurodegenerative diseases, and viral infections, highlighting its potential as a therapeutic target. Commercial CCNT2 antibodies are typically validated for specificity and sensitivity across species, including human and mouse models.
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