| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CCNG2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CCNG2抗体的3篇参考文献示例(注：内容为模拟虚构，仅供参考格式)：
1. **标题**: "CCNG2 Expression in Breast Cancer: A Novel Prognostic Marker"
**作者**: Li, X., et al.
**摘要**: 研究通过免疫组化分析CCNG2在乳腺癌组织中的表达水平，发现其低表达与患者预后不良相关，提示CCNG2可能作为抑癌基因参与细胞周期调控。
2. **标题**: "Development of a Monoclonal Antibody Specific for Human CCNG2 and Its Application in Glioblastoma Studies"
**作者**: Smith, J.R., et al.
**摘要**: 报道了一种高特异性CCNG2单克隆抗体的制备，并验证其在胶质母细胞瘤模型中的应用，发现CCNG2缺失促进肿瘤细胞异常增殖。
3. **标题**: "CCNG2 Regulates DNA Damage Response via p53-Dependent Pathway"
**作者**: Wang, Y., et al.
**摘要**: 利用CCNG2抗体进行蛋白质互作实验，揭示CCNG2通过稳定p53蛋白参与DNA损伤修复机制，为癌症治疗提供潜在靶点。
*提示*：实际文献建议通过PubMed或Web of Science以"CCNG2 antibody"或"Cyclin G2 biomarker"为关键词检索，并筛选近5年高被引研究。
The CCNG2 antibody is a crucial tool for studying Cyclin G2 (CCNG2), a member of the cyclin protein family involved in cell cycle regulation. Unlike canonical cyclins that promote cell cycle progression, Cyclin G2 is associated with inhibitory roles, including cell cycle arrest, differentiation, and apoptosis. It interacts with cyclin-dependent kinase (CDK) inhibitors and modulates pathways like the PI3K-AKT and p53 signaling networks. CCNG2 expression is often downregulated in cancers (e.g., breast, ovarian, and liver cancers), suggesting tumor-suppressive functions, though its role can vary depending on cellular context.
CCNG2 antibodies enable the detection and quantification of Cyclin G2 in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. These antibodies are vital for exploring CCNG2's involvement in diseases, including cancer progression, neurodegenerative disorders, and metabolic syndromes. Researchers also use them to study post-translational modifications and subcellular localization of Cyclin G2. which influence its stability and activity. Despite its established role in cell cycle inhibition, some studies report context-dependent pro-proliferative effects, highlighting the need for further research. CCNG2 antibodies thus serve as essential reagents for elucidating the protein's dual regulatory mechanisms and therapeutic potential.
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