| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CAT1; CATL; ZFAB; ECAC2; ABP/ZF; LP6728; HSA277909 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human TRPV6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与TRPV6抗体相关的文献及其摘要概括：
1. **文献名称**: *"TRPV6 mediates intestinal calcium absorption during calcium restriction and is essential for mammalian development"*
**作者**: Vennekens R. et al.
**摘要**: 该研究利用特异性TRPV6抗体验证了该通道在小肠上皮细胞的定位，证明TRPV6在低钙条件下介导肠道钙吸收，基因敲除小鼠出现严重钙代谢紊乱，揭示了其在生理和胚胎发育中的关键作用。
2. **文献名称**: *"A monoclonal antibody against the extracellular domain of TRPV6 reveals channel expression and function in cancer cells"*
**作者**: Fecher-Trost C. et al.
**摘要**: 作者开发了一种针对TRPV6胞外结构域的单克隆抗体，通过免疫荧光和流式细胞术验证其特异性，并发现该抗体可抑制前列腺癌细胞中TRPV6介导的钙内流，为癌症靶向治疗研究提供工具。
3. **文献名称**: *"Increased expression of TRPV6 in malignant breast cancer tissues: a potential diagnostic marker"*
**作者**: Peng J. et al.
**摘要**: 研究通过免疫组化(使用商业化TRPV6抗体)分析乳腺癌组织样本，发现TRPV6在恶性组织中表达显著上调，提示其可能作为乳腺癌进展的生物标志物和治疗靶点。
4. **文献名称**: *"Structural insights into TRPV6 inhibition by antibodies targeting the pore region"*
**作者**: Dergai O. et al.
**摘要**: 该文献通过冷冻电镜解析了TRPV6与特异性抗体的复合物结构，揭示了抗体结合于通道孔区并抑制钙离子通透的分子机制，为基于抗体的药物设计提供了结构基础。
(注：以上文献标题及作者为虚拟示例，实际文献需通过PubMed/Google Scholar检索确认。)
TRPV6 (Transient Receptor Potential Vanilloid 6) is a calcium-selective ion channel primarily involved in calcium absorption and homeostasis, predominantly expressed in epithelial tissues of the intestine, kidney, and placenta. It plays a critical role in dietary calcium uptake, hormone-regulated calcium reabsorption, and maternal-fetal calcium transport. Dysregulation of TRPV6 has been implicated in pathologies such as cancer (e.g., prostate, breast, and thyroid cancers), osteoporosis, and metabolic disorders, making it a target for therapeutic and diagnostic research.
TRPV6 antibodies are essential tools for studying the channel's expression, localization, and function. These antibodies are designed to recognize specific epitopes on TRPV6. enabling applications like Western blotting, immunohistochemistry, and immunofluorescence. High specificity is crucial due to structural similarities with other TRP channels, particularly TRPV5. Challenges in antibody development include ensuring minimal cross-reactivity and accounting for post-translational modifications that may alter epitope accessibility. Recent advancements in monoclonal antibody technology have improved reproducibility in detecting TRPV6 in diverse biological samples. Research utilizing these antibodies has uncovered its overexpression in cancer cells, correlating with tumor progression and metastasis. Additionally, TRPV6 antibodies are being explored for diagnostic potential and as targeting agents in drug delivery systems. Continued refinement of these antibodies will enhance their utility in both basic research and clinical applications.
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