Rabbit Polyclonal NDUFB2 Antibody

The NDUFB2 antibody is a specialized tool used to detect the NADH:ubiquinone oxidoreductase subunit B2 (NDUFB2), a core component of mitochondrial Complex I (NADH dehydrogenase) in the electron transport chain. Complex I, the largest respiratory complex, plays a critical role in oxidative phosphorylation by catalyzing electron transfer from NADH to ubiquinone, coupled with proton translocation. NDUFB2 is a nuclear-encoded, membrane-bound subunit integral to Complex I’s structural and functional integrity. Antibodies targeting NDUFB2 are essential for studying Complex I assembly, stability, and dysfunction linked to mitochondrial disorders (e.g., Leigh syndrome, Leber hereditary optic neuropathy) and metabolic diseases. These antibodies are validated for applications like Western blotting, immunofluorescence, and immunohistochemistry to assess protein expression, localization, and deficiency in tissues or cell models. Researchers also use NDUFB2 antibodies to explore metabolic alterations in cancer, neurodegeneration (e.g., Parkinson’s disease), and aging. High-quality NDUFB2 antibodies exhibit specificity confirmed by knockdown/knockout controls and cross-reactivity testing. Their utility extends to both basic mitochondrial biology and clinical research, aiding in diagnostics and therapeutic development for energy metabolism-related pathologies.