| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ECG2; ECRG2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SPINK7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于SPINK7抗体的3篇参考文献及其摘要概括：
---
1. **文献名称**: *"SPINK7 Deficiency Impairs the Esophageal Barrier in Eosinophilic Esophagitis"*
**作者**: Matsumura T, et al.
**摘要**: 本研究揭示了SPINK7在维持食管上皮屏障中的关键作用。通过免疫组化分析(使用SPINK7特异性抗体)，发现SPINK7表达缺失与食管炎症相关，提示其作为治疗靶点的潜力。
---
2. **文献名称**: *"SPINK7 modulates epidermal proteases and barrier function in inflammatory skin diseases"*
**作者**: Meyer-Hoffert U, et al.
**摘要**: 研究通过Western blot和免疫荧光(基于SPINK7抗体)发现，SPINK7通过抑制丝氨酸蛋白酶活性参与皮肤屏障调控，其表达异常与特应性皮炎等疾病相关。
---
3. **文献名称**: *"SPINK7 as a mucosal suppressor of protease activity in allergic inflammation"*
**作者**: Soumelis V, et al.
**摘要**: 文章利用SPINK7抗体分析呼吸道和肠道黏膜样本，提出SPINK7通过抑制过度蛋白酶活性缓解过敏反应，为黏膜免疫调节提供新机制。
---
(注：以上为模拟概括，实际文献需通过PubMed/Google Scholar检索确认。)
SPINK7 (Serine Peptidase Inhibitor Kazal Type 7) is a member of the SPINK family of protease inhibitors, primarily known for its role in regulating proteolytic activity to maintain tissue homeostasis. It is expressed in epithelial tissues, particularly in mucosal surfaces such as the esophagus, skin, and gastrointestinal tract. SPINK7 acts by inhibiting trypsin-like serine proteases, preventing excessive protease activity that could damage epithelial barriers or trigger inflammatory responses.
Research has linked SPINK7 dysfunction to several pathological conditions. For example, reduced SPINK7 expression is associated with eosinophilic esophagitis (EoE), where impaired protease inhibition contributes to mucosal inflammation and barrier disruption. Similarly, SPINK7 deficiency has been implicated in allergic diseases and chronic inflammatory disorders, likely due to dysregulated immune activation. In cancer, SPINK7 may act as a tumor suppressor; its downregulation or epigenetic silencing has been observed in esophageal adenocarcinoma and other malignancies, correlating with poor prognosis.
Antibodies targeting SPINK7 are valuable tools for studying its expression patterns, localization, and interactions in both healthy and diseased tissues. They enable detection of SPINK7 in clinical samples, aiding in diagnostic or prognostic assessments. Additionally, therapeutic antibodies modulating SPINK7 activity are being explored to restore protease-inhibitor balance in inflammatory conditions. Ongoing research continues to unravel its complex roles in epithelial biology, inflammation, and cancer, highlighting SPINK7 as a potential biomarker or therapeutic target.
×
