| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CX45; GJA7 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GJC1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GJC1抗体的3篇代表性文献摘要(基于公开信息整理，非真实文献，仅供示例参考)：
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1. **文献名称**: *GJC1 (Connexin 45) Antibody Validation in Cardiac Tissue*
**作者**: Smith A, et al.
**摘要**: 本研究验证了GJC1抗体在心脏组织中的特异性，发现其在心肌闰盘处高表达，并证实其与心律失常相关的缝隙连接功能异常相关。抗体通过Western blot和免疫荧光验证了特异性。
2. **文献名称**: *Role of GJC1 in Oligodendrocyte Development: Insights from Antibody-Based Knockdown*
**作者**: Lee B, et al.
**摘要**: 利用GJC1抗体阻断实验，揭示了GJC1蛋白在少突胶质细胞分化中的关键作用，证明其表达缺失导致髓鞘形成障碍，为多发性硬化症研究提供新靶点。
3. **文献名称**: *GJC1 Antibody Application in Tumor Microenvironment Analysis*
**作者**: Chen X, et al.
**摘要**: 通过GJC1抗体标记肿瘤间质细胞，发现高表达GJC1与乳腺癌转移相关，提示其可能通过调节细胞间通讯促进肿瘤侵袭，抗体特异性经流式细胞术验证。
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如需真实文献，建议在PubMed或Google Scholar中检索关键词：**GJC1 antibody**、**Connexin 45 antibody**，并筛选近年的功能研究或抗体应用类论文。
The GJC1 antibody targets the Gap Junction Gamma-1 protein (GJC1), also known as Connexin 43 (Cx43), a key component of gap junctions. These intercellular channels facilitate direct communication between adjacent cells by allowing the exchange of ions, metabolites, and signaling molecules. GJC1 is widely expressed in tissues such as the heart, brain, skin, and blood vessels, playing critical roles in maintaining electrical coupling, tissue homeostasis, and coordinated cellular responses. Dysregulation of GJC1 has been implicated in pathologies including cardiac arrhythmias, neurodegenerative disorders, wound healing defects, and cancer metastasis.
Antibodies against GJC1 are essential tools for studying its expression, localization, and function. They are used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels, tissue distribution, and cellular dynamics. Research utilizing GJC1 antibodies has revealed its involvement in cell proliferation, apoptosis, and inflammation, with altered expression patterns observed in disease models. For instance, reduced Cx43 levels in cardiomyocytes correlate with arrhythmogenesis, while its overexpression in tumors may influence cell migration.
Additionally, GJC1 antibodies aid in exploring therapeutic strategies targeting gap junction communication. Mutations in the GJC1 gene are linked to oculodentodigital dysplasia and hearing loss, highlighting its clinical relevance. These antibodies thus serve both diagnostic and mechanistic research purposes, bridging molecular insights to potential clinical applications.
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