| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CATL1; CPT1P; CPTIC; SPG73; CPT1-B; CPTI-B |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human CPT1C |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于 **CPT1C抗体** 的3篇代表性文献摘要(虚构示例，供参考)：
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1. **文献名称**: *"CPT1C regulates lipid metabolism in hypothalamic neurons and modulates energy homeostasis"*
**作者**: Rodríguez E, et al.
**摘要**: 本研究利用特异性CPT1C抗体，通过免疫印迹和免疫组化技术，揭示了CPT1C在下丘脑神经元中对脂质代谢的关键调控作用，并发现其缺失导致小鼠能量平衡失调和肥胖表型。
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2. **文献名称**: *"A novel monoclonal antibody against CPT1C detects its expression in aggressive gliomas"*
**作者**: Wang L, et al.
**摘要**: 文章报道了一种新型CPT1C单克隆抗体的开发与验证，该抗体在胶质瘤组织样本中特异性识别CPT1C蛋白，证实其在恶性胶质瘤中高表达，并与患者预后不良相关。
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3. **文献名称**: *"CPT1C-mediated fatty acid oxidation promotes cancer cell survival under nutrient stress"*
**作者**: Sanchez M, et al.
**摘要**: 通过CPT1C抗体的应用，研究发现肿瘤细胞在营养缺乏时依赖CPT1C介导的脂肪酸氧化维持存活，提示其作为潜在治疗靶点。抗体特异性在基因敲除模型中得到验证。
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如需真实文献，建议在 **PubMed** 或 **Google Scholar** 检索关键词“CPT1C antibody”、“CPT1C biomarker”或“CPT1C carnitine palmitoyltransferase”。
**Background of CPT1C Antibody**
CPT1C (carnitine palmitoyltransferase 1C) is a lesser-studied isoform of the CPT1 enzyme family, which plays a critical role in fatty acid metabolism by regulating the transport of long-chain fatty acids into mitochondria for β-oxidation. Unlike CPT1A (liver isoform) and CPT1B (muscle isoform), CPT1C is primarily expressed in the brain, particularly in neurons, and is localized to the endoplasmic reticulum rather than mitochondria. Its precise biological function remains unclear, but studies suggest involvement in lipid sensing, energy homeostasis, and synaptic plasticity. CPT1C has been linked to metabolic disorders, neurodegenerative diseases, and cancer, with emerging roles in regulating cellular stress responses and tumor survival under nutrient deprivation.
CPT1C antibodies are essential tools for detecting and quantifying CPT1C protein levels in research. They enable investigations into its expression patterns, subcellular localization, and interactions in various tissues and disease models. Validated antibodies are critical due to high sequence homology among CPT1 isoforms, which can lead to cross-reactivity if not carefully characterized. Applications include Western blotting, immunohistochemistry, and immunofluorescence, aiding studies on metabolic dysregulation, brain function, and cancer biology. Recent research highlights CPT1C's potential as a therapeutic target, emphasizing the need for reliable antibodies to explore its mechanistic roles and clinical relevance.
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