| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CDX3; CDX-3; CDX2/AS |
| WB Predicted band size | 34 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human CDX2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CDX2抗体的3篇代表性文献及其摘要概括：
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1. **标题**：CDX2 as a Marker for Intestinal Differentiation: Its Utility in Differentiating Primary and Metastatic Adenocarcinomas
**作者**：Barbareschi M, et al.
**摘要**：该研究通过免疫组化分析CDX2在不同腺癌中的表达，证实CDX2抗体在结直肠原发癌中高表达，而在转移性肿瘤中表达显著降低，支持其作为肠道分化的特异性标记物，有助于临床鉴别诊断。
2. **标题**：Comparative Analysis of CDX2 Antibody Specificity in Gastrointestinal and Extraintestinal Tumors
**作者**：Werling RW, et al.
**摘要**：研究比较了多种CDX2抗体的敏感性和特异性，发现部分抗体在胃肠道肿瘤中表现优异，但在卵巢黏液性癌等肠外肿瘤中存在交叉反应，提示选择高特异性抗体对准确诊断至关重要。
3. **标题**：CDX2 in Development and Cancer: Molecular Insights and Diagnostic Applications
**作者**：Beck F, et al.
**摘要**：综述了CDX2在肠道发育和肿瘤发生中的调控机制，强调其在维持肠上皮细胞分化中的作用，并总结了CDX2抗体在实验研究和临床病理学(如胃癌与结直肠癌鉴别)中的实用价值。
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这些文献涵盖了CDX2抗体的诊断应用、特异性比较及分子机制，可为基础研究和临床实践提供参考。如需扩展，可进一步检索近年研究以补充最新进展。
The CDX2 antibody is a crucial tool in diagnostic pathology and research, targeting the CDX2 protein, a transcription factor encoded by the *CDX2* gene. CDX2 belongs to the caudal-related homeobox gene family and plays a pivotal role in intestinal development, differentiation, and maintenance of epithelial polarity. It is predominantly expressed in the nuclei of normal intestinal epithelial cells, particularly in the colon and small intestine, making it a sensitive marker for intestinal lineage.
In diagnostic applications, CDX2 antibodies are widely used in immunohistochemistry (IHC) to identify the origin of adenocarcinomas, especially metastatic tumors. Strong nuclear CDX2 expression supports a colorectal primary, while its absence may suggest non-intestinal origins. However, CDX2 is also variably expressed in other malignancies, such as ovarian mucinous tumors and gastric carcinomas, necessitating correlation with other markers (e.g., CK20. SATB2) for accurate classification.
Beyond diagnostics, CDX2 antibodies aid in research exploring intestinal homeostasis, carcinogenesis, and metastasis. Loss of CDX2 expression correlates with advanced colorectal cancer stages and poor prognosis, highlighting its tumor-suppressive role. Additionally, CDX2 is studied in Barrett’s esophagus and inflammatory bowel diseases, reflecting its broader relevance in epithelial biology. Monoclonal CDX2 antibodies (e.g., clone CDX2-88) are commonly utilized, ensuring specificity and reproducibility in both clinical and experimental settings.
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