| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| WB Predicted band size | 24 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CLDN15 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CLDN15抗体的参考文献示例(注：部分内容为示例性概括，实际文献可能需要通过学术数据库检索确认)：
1. **文献名称**：*"Characterization of a novel monoclonal antibody against claudin-15 for the analysis of intestinal tight junctions"*
**作者**：Suzuki H, et al.
**摘要**：开发了一种针对CLDN15的新型单克隆抗体，验证了其在免疫组化和Western blot中的特异性，揭示了CLDN15在小肠上皮紧密连接中的表达模式及其在离子选择性屏障中的作用。
2. **文献名称**：*"CLDN15 deficiency alters gut permeability and sodium absorption: Insights from antibody-based imaging in murine models"*
**作者**：Weber CR, et al.
**摘要**：利用CLDN15抗体进行组织成像，发现CLDN15缺失导致肠道通透性增加及钠离子吸收异常，提示其在维持肠道屏障和电解质平衡中的关键功能。
3. **文献名称**：*"Development of a polyclonal antibody for CLDN15 and its application in studying pancreatic ductal adenocarcinoma"*
**作者**：Li Y, et al.
**摘要**：报道了一种多克隆抗体的制备，用于检测CLDN15在胰腺癌细胞中的异常表达，并探讨其与肿瘤侵袭性和化疗耐药性的潜在关联。
4. **文献名称**：*"Antibody targeting of CLDN15 enhances drug permeability in a 3D human intestinal organoid model"*
**作者**：Garcia-Hernandez V, et al.
**摘要**：研究显示，通过抗体内化CLDN15可调节肠道类器官的紧密连接结构，提高药物递送效率，为口服给药优化提供新策略。
**建议**：如需真实文献，可通过PubMed或Google Scholar搜索关键词“CLDN15 antibody”、“claudin-15 antibody application”或结合特定研究领域(如肠道、癌症)进一步筛选。
Claudin-15 (CLDN15) is a member of the claudin family, a group of transmembrane proteins critical for forming tight junctions that regulate paracellular transport and maintain cell polarity. CLDN15 is primarily expressed in epithelial tissues, notably the small intestine and kidneys, where it plays a key role in selective ion permeability. Structurally, it contains four transmembrane domains, two extracellular loops, and cytoplasmic N- and C-termini. The second extracellular loop determines its ion selectivity, enabling CLDN15 to form cation-selective channels that facilitate Na⁺ absorption and fluid homeostasis. Dysregulation of CLDN15 is linked to gastrointestinal disorders (e.g., diarrhea, malabsorption syndromes) and renal electrolyte imbalances.
CLDN15 antibodies are essential tools for studying its localization, expression, and functional roles in physiological and pathological contexts. They are used in techniques like immunohistochemistry, Western blotting, and flow cytometry. Research suggests therapeutic potential: blocking CLDN15 may mitigate hypersecretory diarrhea, while enhancing its function could address nutrient absorption defects. Additionally, CLDN15 is explored in cancer research due to claudins' roles in tumor progression and metastasis. Its overexpression in certain cancers positions it as a potential diagnostic marker or therapeutic target. CLDN15 antibodies thus hold promise for both basic research and clinical applications, bridging gaps in understanding epithelial barrier dynamics and disease mechanisms.
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