Rabbit Polyclonal CMKLR1 Antibody

CMKLR1 (Chemokine-like receptor 1), also known as ChemR23 or chemerin receptor, is a G protein-coupled receptor (GPCR) that binds the adipokine chemerin and resolvin E1. It plays critical roles in immune regulation, inflammation resolution, and metabolic processes. Expressed primarily in immune cells (e.g., macrophages, dendritic cells) and adipose tissue, CMKLR1 mediates chemotaxis, cell adhesion, and cytokine production upon activation. Its involvement in diseases like obesity, diabetes, cancer, and chronic inflammation has driven research interest. CMKLR1 antibodies are essential tools for detecting receptor expression, elucidating signaling pathways, and exploring therapeutic targeting. These antibodies (monoclonal/polyclonal) are used in techniques like Western blotting, immunohistochemistry, and flow cytometry to study receptor localization, expression levels, and interaction mechanisms. Recent studies focus on CMKLR1's dual pro- and anti-inflammatory roles, its crosstalk with metabolic pathways, and potential as a biomarker or drug target for metabolic syndromes or autoimmune disorders. Validation of antibody specificity remains crucial due to structural similarities among GPCRs.